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Titolo:
BMP and FGF regulate the development of EGF-responsive neural progenitor cells
Autore:
Lillien, L; Raphael, H;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 urobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Pittsburgh Canc Inst, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 nc Inst, Pittsburgh, PA 15261 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 22, volume: 127, anno: 2000,
pagine: 4993 - 5005
SICI:
0950-1991(200011)127:22<4993:BAFRTD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; BONE MORPHOGENETIC PROTEIN-4; CENTRAL-NERVOUS-SYSTEM; RAT CEREBRAL-CORTEX; STEM-CELLS; SUBVENTRICULAR ZONE; CORTICAL-NEURONS; VENTRICULAR ZONE; RESTRICTED PRECURSORS; IN-VITRO;
Keywords:
cerebral cortex; proliferation; EGF receptor; stem cell; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Lillien, L Univ Pittsburgh, Sch Med, Dept Neurobiol, W1454 Biomed Sci Tower, Pittsburgh, PA 15261 USA Univ Pittsburgh W1454 Biomed Sci Tower Pittsburgh PA USA 15261
Citazione:
L. Lillien e H. Raphael, "BMP and FGF regulate the development of EGF-responsive neural progenitor cells", DEVELOPMENT, 127(22), 2000, pp. 4993-5005

Abstract

Temporal changes in progenitor cell responses to extrinsic signals play animportant role in development, but little is known about the mechanisms that determine how these changes occur. In the rodent CNS, expression of epidermal growth factor receptors (EGFRs) increases during embryonic development, conferring mitotic responsiveness to EGF among multipotent stem cells, Here we show that cell-cell signaling controls this change. Whereas EGF-responsive stem cells develop on schedule in explant and aggregate cultures of embryonic cortex, co-culture with younger cortical cells delays their development. Exogenous BMP4 mimics the effect of younger cells, reversibly inhibiting changes in EGFR expression and responsiveness. Moreover, blocking endogenous BMP receptors in progenitors with a virus transducing dnBMPR1B accelerates changes in EGFR signaling. This involves a non-cell-autonomous mechanism, suggesting that BMP negatively regulates signal(s) that promote the development of EGF-responsive stem cells. FGF2 is a good candidate for sucha signal, as we find that it antagonizes the inhibitory effects of youngercortical cells and exogenous BMP4, These findings suggest that a balance between antagonistic extrinsic signals regulates temporal changes in an intrinsic property of neural progenitor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:05:42