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Titolo:
Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice
Autore:
Barallobre, MJ; Del Rio, JA; Alcantara, S; Borrell, V; Aguado, F; Ruiz, M; Carmona, MA; Martin, M; Fabre, M; Yuste, R; Tessier-Lavigne, M; Soriano, E;
Indirizzi:
Univ Barcelona, Dept Cell Biol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 ll Biol, E-08028 Barcelona, Spain Univ Barcelona, CERN, Neurosci Res Ctr, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 Res Ctr, E-08028 Barcelona, Spain Inst Municipal Invest Med, Unitat Biol Cellular & Mol, E-08003 Barcelona, Spain Inst Municipal Invest Med Barcelona Spain E-08003 08003 Barcelona, Spain Columbia Univ, Dept Biol Sci, New York, NY 10027 USA Columbia Univ New York NY USA 10027 Dept Biol Sci, New York, NY 10027 USA Univ Calif San Francisco, Howard Hughes Med Inst, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 22, volume: 127, anno: 2000,
pagine: 4797 - 4810
SICI:
0950-1991(200011)127:22<4797:ADOHCA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN SUPERFAMILY MEMBER; VERTEBRATE NERVOUS-SYSTEM; REPULSIVE AXON GUIDANCE; CAJAL-RETZIUS CELLS; COMMISSURAL AXONS; FIBER TRACTS; C-ELEGANS; CONNECTIONS; RECEPTORS; NEURONS;
Keywords:
hippocampal development; circuit formation; DCC receptor; axonal navigation; chemoattraction; neural activity; hippocampal commissure; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Soriano, E Univ Barcelona, Dept Cell Biol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 08028 Barcelona, Spain
Citazione:
M.J. Barallobre et al., "Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice", DEVELOPMENT, 127(22), 2000, pp. 4797-4810

Abstract

Diffusible factors, including netrins and semaphorins, are believed to be important cues for the formation of neural circuits in the forebrain, Here we have examined the role of netrin 1 in the development of hippocampal connections, We show that netrin I and its receptor, Dcc, are expressed in thedeveloping fimbria and in projection neurons, respectively, and that netrin 1 promotes the outgrowth of hippocampal axons in vitro via DCC receptors,We also show that the hippocampus of netrin 1-deficient mice shows a misorientation of fiber tracts and pathfinding errors, as detected with antibodies against the surface proteins TAG-1, L1 and DCC, DiI injections show thathippocampal commissural axons do not cross the midline in these mutants. Instead, when axons approach the midline, they turn ventrally and form a massive aberrant projection to the ipsilateral septum, In addition, both the ipsilateral entorhino-hippocampal and the CA3-to-CA1 associational projections show an altered pattern of layer-specific termination in netrin 1-deficient mice. Finally, optical recordings with the Ca2+ indicator Fura 2-AM show that spontaneous neuronal activity is reduced in the septum of netrin 1-mutant mice, We conclude that netrin 1 is required not only fbr the formation of crossed connections in the forebrain, but also for the appropriate layer-specific targeting of ipsilateral projections and for the control of normal levels of spontaneous neural activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:48:01