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Titolo:
Zaleplon: A pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia
Autore:
Weitzel, KW; Wickman, JM; Augustin, SG; Strom, JG;
Indirizzi:
Mercer Univ, Sch Pharm, Dept Pharm Practice, Atlanta, GA USA Mercer Univ Atlanta GA USA h Pharm, Dept Pharm Practice, Atlanta, GA USA Mercer Univ, Sch Pharm, Dept Pharmaceut Sci, Atlanta, GA USA Mercer Univ Atlanta GA USA h Pharm, Dept Pharmaceut Sci, Atlanta, GA USA
Titolo Testata:
CLINICAL THERAPEUTICS
fascicolo: 11, volume: 22, anno: 2000,
pagine: 1254 - 1267
SICI:
0149-2918(200011)22:11<1254:ZAPSAF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRIVING PERFORMANCE; DRUGS; PSYCHOMOTOR; ZOLPIDEM; EFFICACY; PLACEBO; QUESTIONNAIRE; VOLUNTEERS; MANAGEMENT; METABOLISM;
Keywords:
zaleplon; insomnia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Weitzel, KW Univ Florida, Coll Pharm, Dept Pharm Practice, HSC, Box 100486, Gainesville, FL 32610 USA Univ Florida Box 100486 Gainesville FL USA 32610 FL 32610 USA
Citazione:
K.W. Weitzel et al., "Zaleplon: A pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia", CLIN THER, 22(11), 2000, pp. 1254-1267

Abstract

Background: Insomnia is the subjective complaint of poor sleep or an inadequate amount of sleep that adversely affects daily functioning. For the past 4 decades, treatment of insomnia has shifted away from the use of barbiturates toward the use of hypnotic agents: of the benzodiazepine class. However, problems associated with the latter leg, next-day sedation, rebound insomnia, dependence, and tolerance) have prompted development of other agents. Objective: This review describes the recently approved nonbenzodiazepine agent, zaleplon. Methods: Studies of zaleplon were identified through a search of English-language articles listed in MEDLINE(R) and International Pharmaceutical Abstracts, with no limitation on year. These were supplemented by educational materials from conferences. Results: The efficacy and tolerability of zaleplon have been documented inthe literature. Zaleplon has been shown to improve sleep variables in comparison with placebo. Like most hypnotic agents, zaleplon can be used for problems of sleep initiation at the beginning of the night, but its short duration of clinical effect may also allow patients to take it later in the night without residual effects the next morning. Zaleplon can be taken less than or equal to2 hours before awakening without "hangover" effects. It is generally well tolerated, with headache being the most commonly reported adverse event in clinical trials (15% -18%). Compared with flurazepam, a long-acting benzodiazepine sedative-hypnotic agent, zaleplon causes significantly less psychomotor and cognitive impairment (P < 0.001). Zaleplon has not been studied in pregnant women or children. The dose of zaleplon should be individualized; the recommended daily dose for most adults is 10 mg. Conclusions: Insomnia has a substantial impact on daily functioning. If pharmacologic treatment is indicated for insomnia, the choice of an agent Should be guided by individual patient characteristics.

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Documento generato il 04/12/20 alle ore 22:19:20