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Titolo:
A randomized, double-blind trial comparing azithromycin and clarithromycinin the treatment of disseminated Mycobacterium avium infection in patientswith human immunodeficiency virus
Autore:
Dunne, M; Fessel, J; Kumar, P; Dickenson, G; Keiser, P; Boulos, M; Mogyros, M; White, AC; Cahn, P; OConnor, M; Lewi, D; Green, S; Tilles, J; Hicks, C; Bissett, J; Schneider, MME; Benner, R;
Indirizzi:
Pfizer Inc, Pfizer Cent Res, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 Inc, Pfizer Cent Res, Groton, CT 06340 USA Kaiser Permanente, San Francisco, CA USA Kaiser Permanente San Francisco CA USA Permanente, San Francisco, CA USA Univ Calif Irvine, Med Ctr, Orange, CA USA Univ Calif Irvine Orange CA USA iv Calif Irvine, Med Ctr, Orange, CA USA Georgetown Univ, Washington, DC USA Georgetown Univ Washington DC USAGeorgetown Univ, Washington, DC USA Vet Affairs Med Ctr, Miami, FL 33125 USA Vet Affairs Med Ctr Miami FL USA33125 fairs Med Ctr, Miami, FL 33125 USA Parkland Mem Hosp, Dallas, TX USA Parkland Mem Hosp Dallas TX USAParkland Mem Hosp, Dallas, TX USA Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA Austin Infect Dis Consultants, Austin, TX USA Austin Infect Dis Consultants Austin TX USA Consultants, Austin, TX USA Franklin Med Ctr, Denver, CO USA Franklin Med Ctr Denver CO USAFranklin Med Ctr, Denver, CO USA Trinity Lutheran Hosp, Kansas City, MO USA Trinity Lutheran Hosp Kansas City MO USA heran Hosp, Kansas City, MO USA Hampton Roads Med Specialists, Hampton, VA USA Hampton Roads Med Specialists Hampton VA USA pecialists, Hampton, VA USA Duke Univ, Med Ctr, Durham, NC USA Duke Univ Durham NC USADuke Univ, Med Ctr, Durham, NC USA Hosp Clin, Sao Paulo, Brazil Hosp Clin Sao Paulo BrazilHosp Clin, Sao Paulo, Brazil Sch Paulista Med, Sao Paulo, Brazil Sch Paulista Med Sao Paulo BrazilSch Paulista Med, Sao Paulo, Brazil HUESPED Fdn, Buenos Aires, DF, Argentina HUESPED Fdn Buenos Aires DF Argentina D Fdn, Buenos Aires, DF, Argentina Univ Utrecht, Med Ctr, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands Utrecht, Med Ctr, Utrecht, Netherlands
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 5, volume: 31, anno: 2000,
pagine: 1245 - 1252
SICI:
1058-4838(200011)31:5<1245:ARDTCA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS PATIENTS; COMPLEX BACTEREMIA; DISEASE; ETHAMBUTOL; RIFABUTIN; INTRACELLULARE; THERAPY; CLOFAZIMINE; MORTALITY; REGIMENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Dunne, M Pfizer Inc, Pfizer Cent Res, Eastern Point Rd, Groton, CT 06340 USA Pfizer Inc Eastern Point Rd Groton CT USA 06340 ton, CT 06340 USA
Citazione:
M. Dunne et al., "A randomized, double-blind trial comparing azithromycin and clarithromycinin the treatment of disseminated Mycobacterium avium infection in patientswith human immunodeficiency virus", CLIN INF D, 31(5), 2000, pp. 1245-1252

Abstract

Two hundred and forty-six patients infected with human immunodeficiency virus (HIV) who also had disseminated Mycobacteiium avium complex received either azithromycin 250 mg every day, azithromycin 600 mg every day, or clarithromycin 500 mg twice a day, each combined with ethambutol, for 24 weeks. Samples drawn from patients were cultured and clinically assessed every 3 weeks up to week 12, then monthly thereafter through week 24 of double-blindtherapy and every 3 months while on open-label therapy through the conclusion of the trial. The azithromycin 250 mg arm of the study was dropped after an interim analysis showed a lower rate of clearance of bacteremia, At 24weeks of therapy, the likelihood of patients' developing 2 consecutive negative cultures (46% vs. 56%, P = .24) or 1 negative culture (59% vs. 61%, P=.80) was similar for azithromycin 600 mg (n = 68) and clarithromycin (n =57), respectively. The likelihood of relapse was 39% versus 27% (P = .21) on azithromycin compared with clarithromycin, respectively. Of the 6 patients who experienced relapse, those randomized to azithromycin developed isolates resistant to macrolides, compared with 2 of 3 patients randomized to clarithromycin. Mortality was similar in patients comprising each arm of thestudy (69% vs. 63%; hazard, 95.1% confidence interval, 1.1 [0.7, 1.7]), Azithromycin 600 mg, when given in combination with ethambutol, is an effective agent for the treatment of disseminated M. avium disease in patients infected with HIV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 01:36:18