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Titolo:
Lipophilicity determination of N-(benzothiazol-2-yl)-alpha-amino alkyl phosphonic diesters by RP-HPLC and RP-HPTLC
Autore:
Zhang, L; Li, ZG; Huang, RQ; Wang, QS;
Indirizzi:
Nankai Univ, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China Nankai Univ Tianjin Peoples R China 300071 anjin 300071, Peoples R China
Titolo Testata:
CHINESE JOURNAL OF CHEMISTRY
fascicolo: 6, volume: 18, anno: 2000,
pagine: 872 - 876
SICI:
1001-604X(200011/12)18:6<872:LDONAP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY;
Keywords:
reversed-phase HPLC; reversed-phase HPTLC; N-(benzothiazol-2-yl)-alpha-amino alkyl phosphonic diesters; lipophilicity determination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, QS Nankai Univ, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China Nankai Univ Tianjin Peoples R China 300071 071, Peoples R China
Citazione:
L. Zhang et al., "Lipophilicity determination of N-(benzothiazol-2-yl)-alpha-amino alkyl phosphonic diesters by RP-HPLC and RP-HPTLC", CHIN J CHEM, 18(6), 2000, pp. 872-876

Abstract

Using methanol-water mixtures as the mobile phase, the chromatographic retention parameters k' and R-f were determined by reversed-phase high-performance liquid chromatography (RP-HPLC) and reversed-phase high-performance thin-layer chromatography (RP-HPTLC) for N-(benzothlazol-2-yl)-alpha -amino alkyl phosphonic diesters and the correlation with lipophilicity parameter (ClogP) was established. Logk(w) values obtained from RP-HPLC and R-m0 values obtained from RP-HPTLC can be used to evaluate the lipophilicity of this kind of compounds. Chromatographic method is a good alternative for lipophilicity measurement.

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Documento generato il 05/04/20 alle ore 05:09:07