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Titolo:
Decreased levels of complex III core protein 1 and complex V beta chain inbrains from patients with Alzheimer's disease and Down syndrome
Autore:
Kim, SH; Vlkolinsky, R; Cairns, N; Lubec, G;
Indirizzi:
Univ Vienna, Dept Pediat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Pediat, A-1090 Vienna, Austria Univ London Kings Coll, Inst Psychiat, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 12, volume: 57, anno: 2000,
pagine: 1810 - 1816
SICI:
1420-682X(200011)57:12<1810:DLOCIC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOPTOTIC CELL-DEATH; PARKINSONS-DISEASE; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; CYTOCHROME-OXIDASE; GEL-ELECTROPHORESIS; HUNTINGTONS-DISEASE; ELECTRON-TRANSPORT; MITOCHONDRIAL-DNA; RESPIRATORY-CHAIN;
Keywords:
ubiquinol : cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer's disease; Down syndrome; neuronal cell death; neurodegenerative disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lubec, G Univ Vienna, Dept Pediat, Waehringer Guertel 18, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18 Vienna Austria A-1090 Austria
Citazione:
S.H. Kim et al., "Decreased levels of complex III core protein 1 and complex V beta chain inbrains from patients with Alzheimer's disease and Down syndrome", CELL MOL L, 57(12), 2000, pp. 1810-1816

Abstract

Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complexV beta chain in brain regions of Alzheimer's disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V beta chain was significantly reduced ill the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energyrlletabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:27:00