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Titolo:
Towards defining the role of glycans as hardware in information storage and transfer: Basic principles, experimental approaches and recent progress
Autore:
Solis, D; Jimenez-Barbero, J; Kaltner, H; Romero, A; Siebert, HC; von der Lieth, CW; Gabius, HJ;
Indirizzi:
CSIC, Inst Quim Fis Rocasolano, E-28006 Madrid, Spain CSIC Madrid Spain E-28006 nst Quim Fis Rocasolano, E-28006 Madrid, Spain CSIC, Inst Quim Organ, E-28006 Madrid, Spain CSIC Madrid Spain E-28006CSIC, Inst Quim Organ, E-28006 Madrid, Spain CSIC, Ctr Invest Biol, E-28006 Madrid, Spain CSIC Madrid Spain E-28006CSIC, Ctr Invest Biol, E-28006 Madrid, Spain Univ Munich, Inst Physiol Chem, Tierarztliche Fak, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 rarztliche Fak, D-8000 Munich, Germany Deutsch Krebsforschungszentrum, Zent Spekt, D-6900 Heidelberg, Germany Deutsch Krebsforschungszentrum Heidelberg Germany D-6900 elberg, Germany
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 1-2, volume: 168, anno: 2001,
pagine: 5 - 23
SICI:
1422-6405(2001)168:1-2<5:TDTROG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL BETA-LACTOSIDE; C-TYPE LECTIN; PROTEIN-CARBOHYDRATE INTERACTIONS; MALTODEXTRIN-BINDING PROTEIN; BOVINE HEART GALECTIN-1; I-TYPE LECTINS; MOLECULAR RECOGNITION; ANIMAL LECTINS; CELL-SURFACE; PLANT LECTIN;
Keywords:
crystallography; drug design; lectin; molecular modeling; NMR spectroscopy; sugar code;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
199
Recensione:
Indirizzi per estratti:
Indirizzo: Solis, D CSIC, Inst Quim Fis Rocasolano, Serrano 119, E-28006 Madrid, Spain CSIC Serrano 119 Madrid Spain E-28006 119, E-28006 Madrid, Spain
Citazione:
D. Solis et al., "Towards defining the role of glycans as hardware in information storage and transfer: Basic principles, experimental approaches and recent progress", CELLS T ORG, 168(1-2), 2001, pp. 5-23

Abstract

The term 'code' in biological information transfer appears to be tightly and hitherto exclusively connected with the genetic code based on nucleotides and translated into functional activities via proteins. However, the recent appreciation of the enormous coding capacity of oligosaccharide chains of natural glycoconjugates has spurred to give heed to a new concept: versatile glycan assembly by the genetically encoded glycosyltransferases endows cells with a probably not yet fully catalogued array of meaningful messages. Enciphered by sugar receptors such as endogenous lectins the information of code words established by a series of covalently linked monosaccharides as fetters for example guides correct intra- and intercellular routing of glycoproteins, modulates cell proliferation or migration and mediates cell adhesion. Evidently, the elucidation of the structural frameworks and the recognition strategies within the operation of the sugar code poses a fascinating conundrum. The far-reaching impact of this recognition mode on the level of cells, tissues and organs has fueled vigorous investigations to probethe subtleties of protein-carbohydrate interactions. This review presents information on the necessarily concerted approach using X-ray crystallography, molecular modeling, nuclear magnetic resonance spectroscopy, thermodynamic analysis and engineered ligands and receptors. This part of the treatise is flanked by exemplarily chosen insights made possible by these techniques. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:02:33