Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Relationship between interstitial cells of Cajal and enteric motor neuronsin the murine proximal colon
Autore:
Wang, XY; Sanders, KM; Ward, SM;
Indirizzi:
Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA Univ Nevada Reno NV USA 89557 ept Physiol & Cell Biol, Reno, NV 89557 USA
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 3, volume: 302, anno: 2000,
pagine: 331 - 342
SICI:
0302-766X(200012)302:3<331:RBICOC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; IDIOPATHIC INTESTINAL PSEUDOOBSTRUCTION; PIG GASTROINTESTINAL-TRACT; CANINE SMALL-INTESTINE; DEEP MUSCULAR PLEXUS; SMOOTH-MUSCLE CELLS; ULTRASTRUCTURAL-LOCALIZATION; INHIBITORY NEUROTRANSMISSION; RAT ILEUM; IMMUNOREACTIVITY;
Keywords:
interstitial cells of Cajal; enteric nerves; PGP 9.5; nitric oxide synthase; vesicular acetylcholine transporter gastrointestinal tract; mouse (Balb/c);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ward, SM Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA Univ Nevada Reno NV USA 89557 ol & Cell Biol, Reno, NV 89557 USA
Citazione:
X.Y. Wang et al., "Relationship between interstitial cells of Cajal and enteric motor neuronsin the murine proximal colon", CELL TIS RE, 302(3), 2000, pp. 331-342

Abstract

Interstitial cells of Cajal (ICC) are interposed between enteric neurons and smooth muscle cells in gastrointestinal (GI) muscles. The specific relationships between these cells in the murine proximal colon were studied withconventional and immunoelectron microscopy and immunohistochemistry. Intramuscular interstitial cells (IC-IM) formed discrete networks within the circular muscle layer of the murine proximal colon. Nerve trunks ran in close association with IC-IM and individual nerve trunks came into close contact with multiple IC-IM. Conventional electron microscopy revealed very close (less than or equal to 20 nm) associations between nerve fibers and IC-IM. Processes of IC-IM also formed close contacts with neighboring smooth musclecells. At the points of close association between neurons and IC-IM, areasof membrane densification in both pre- and postjunctional cells were present, suggesting specialized contacts or synaptic-like structures. Similar points of contact between neurons and smooth muscle cells were extremely rare. Immunoelectron microscopy demonstrated that IC-IM formed close associations with neurons containing nitric oxide synthase-like immunoreactivity (NOS-LI) or vesicular acetylcholine transporter-like immunoreactivity (vAChT-LI), suggesting innervation by both inhibitory and excitatory motor neurons. IC-IM were also labeled with anti-NOS antibodies. These observations suggest that IC-IM are an integral part of the neuromuscular junction in the colon. These cells may be the primary site of innervation, and neural regulation of the musculature may occur via IC-IM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:14:44