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Titolo:
Activated polymorphonuclear leukocytes and monocytes in the peripheral blood of patients with ischemic heart and brain conditions correspond to the presence of multiple risk factors for atherothrombosis
Autore:
Berliner, S; Rogowski, O; Rotstein, R; Fusman, R; Shapira, I; Bornstein, NM; Prochorov, V; Roth, A; Keren, G; Eldor, A; Zeltser, D;
Indirizzi:
Tel Aviv Univ, Dept Internal Med D, Sackler Fac Med, Tel Aviv Sourasky MedCtr, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 MedCtr, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Dept Neurol, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 ed Ctr, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Dept Cardiol, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 ed Ctr, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Dept Hematol, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 ed Ctr, IL-64239 Tel Aviv, Israel
Titolo Testata:
CARDIOLOGY
fascicolo: 1, volume: 94, anno: 2000,
pagine: 19 - 25
SICI:
0008-6312(2000)94:1<19:APLAMI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ADHESION MOLECULES; UNSTABLE ANGINA; INCREASED EXPRESSION; NEUTROPHIL; ATHEROSCLEROSIS; INJURY; INFLAMMATION; REPERFUSION; STROKE;
Keywords:
ischemic heart disease; ischemic brain disease; leukocyte CD11b/CD18 (or leukocyte integrin);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Berliner, S Tel Aviv Univ, Dept Internal Med D, Sackler Fac Med, Tel Aviv Sourasky MedCtr, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Univ 6 Weizman St Tel Aviv Israel IL-64239 v, Israel
Citazione:
S. Berliner et al., "Activated polymorphonuclear leukocytes and monocytes in the peripheral blood of patients with ischemic heart and brain conditions correspond to the presence of multiple risk factors for atherothrombosis", CARDIOLOGY, 94(1), 2000, pp. 19-25

Abstract

Objective: Risk factors like hypertension, diabetes mellitus, dyslipidemiaand smoking contribute to the pathogenesis of atherothrombosis. We investigated whether the multiplicity of risk factors for atherothrombosis is associated with leukocyte activation. Methods: We examined the availability of CD11b/CD18 antigen on the surface of peripheral blood polymorphonuclear leukocytes and monocytes in patients with acute ischemic heart and brain conditions. Results: There was a highly significant (p < 0.00001) increment in the availability of the CD11b/CD18 antigen on the surface of the polymorphonuclear leukocytes in patients with multiple (2 or more) vascular risk factors [mean fluorescence intensity (MFI) +/- SD, 210 +/- 102] as opposed to individuals with none or 1 risk factor for atherothrombosis (MFI 159 +/- 73). Similar results were observed on the monocytes: 309 +/- 151 and 235 +/- 97, respectively (p < 0.00001). Conclusion: The multiplicity of risk factors for atherothrombosis is associated with the up-regulation of CD11b/CD18 antigen on the surface of peripheral blood polymorphonuclear leukocytes and monocytes, suggesting the presence of an increased inflammatory response and leukocyte activation in these individuals. Copyright (C) 2000 S. Karger AG,Basel.

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Documento generato il 24/11/20 alle ore 14:07:52