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Titolo:
Regulation of CD40L expression on natural killer cells by interleukin-12 and interferon gamma: its role in the elicitation of an effective antitumor immune response
Autore:
Jyothi, MD; Khar, A;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
CANCER IMMUNOLOGY IMMUNOTHERAPY
fascicolo: 10, volume: 49, anno: 2000,
pagine: 563 - 572
SICI:
0340-7004(200012)49:10<563:ROCEON>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD40-CD40 LIGAND INTERACTION; ANTIGEN-PRESENTING CELLS; HUMAN B-CELLS; KAPPA-B; SPONTANEOUS REGRESSION; CYTOKINE RESPONSE; RAT HISTIOCYTOMA; TUMOR-REGRESSION; UP-REGULATION; T-CELLS;
Keywords:
cytokines; CD40-L expression; NK cells; antitumor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Khar, A Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
M.D. Jyothi e A. Khar, "Regulation of CD40L expression on natural killer cells by interleukin-12 and interferon gamma: its role in the elicitation of an effective antitumor immune response", CANCER IMMU, 49(10), 2000, pp. 563-572

Abstract

Effector cell functions are regulated by a number of positive signals for the mediation of antitumor immunity. The CD40 and CD40 ligand (CD40L) interaction has been implicated in the generation of effective cell-mediated andhumoral immune responses, where cytokines have been shown to play a significant role in the expression of these molecules. Our earlier studies have shown that spontaneous regression of a rat histiocytoma transplanted s.c. ismediated by CD8(+) CD3(-) NK cells. The CD40-CD40L mediation during tumor regression was of interest. Tumor-transplanted animals showed enhanced expression of CD40L on natural killer (NK) and T cells, when compared to cells from normal animals. CD40 expression on AK-5 tumor cells was also induced after s.c. transplantation. Administration of anti-(interleukin-12) (anti-IL-12) and anti(interferon gamma) (anti-IFN gamma) antibodies in tumor-bearing animals showed down-regulation of the expression of CD40L on NK and T cells with simultaneous inhibition of cytotoxic activity of NK cells, cytokinerelease and the production of antitumor antibody. Naive NK cells, when co-cultured with fixed AK-5 cells, were induced to express CD40L. CD40L expression modulated the immune response exerted by NK cells, in part by the activation of nuclear factor kappaB (NF-kappaB). Furthermore, the signaling viaCD40L through the use of anti-CD40L antibody promoted the in vitro activation of cytotoxic as well as NF-kappaB binding activity in NK cells from tumor-transplanted animals. These observations demonstrate that the expressionof CD40L by the effector cells is regulated by IL-12 and IFN gamma, and could effectively modulate the NK-cell-mediated immune response during the regression of AK-5 tumor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:07:44