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Titolo:
Involvement of 5-HT3 receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat
Autore:
Herges, S; Taylor, DA;
Indirizzi:
Monash Univ, Victorian Coll Pharm, Dept Pharmaceut Biol & Pharmacol, Parkville, Vic 3052, Australia Monash Univ Parkville Vic Australia 3052 , Parkville, Vic 3052, Australia
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 7, volume: 131, anno: 2000,
pagine: 1294 - 1302
SICI:
0007-1188(200012)131:7<1294:IO5RIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; INDUCED LOCOMOTOR-ACTIVITY; INCREASES EXTRACELLULAR DOPAMINE; BRAIN CORTEX SLICES; MEDIAN RAPHE NUCLEI; SEROTONIN RELEASE; FRONTAL-CORTEX; INVIVO MICRODIALYSIS; IN-VIVO;
Keywords:
cocaine; locomotor activity; fluoxetine; ondansetron: 5-HT3; nucleus accumbens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, DA Monash Univ, Victorian Coll Pharm, Dept Pharmaceut Biol & Pharmacol, 381 Royal Parade, Parkville, Vic 3052, Australia Monash Univ 381 Royal Parade Parkville Vic Australia 3052 ralia
Citazione:
S. Herges e D.A. Taylor, "Involvement of 5-HT3 receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat", BR J PHARM, 131(7), 2000, pp. 1294-1302

Abstract

1 The present study investigated the central effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine and the role of 5-hydroxytryptamine(3) (5-HT3) receptors in the core of the nucleus accumbens (NAc) on cocaine-induced behavioural changes in rats.2 The 5-HT3 receptor antagonist ondansetron (1 or 10 ng) was microinjectedbilaterally into the core of the NAc 60 min prior to peripheral cocaine (15 mg kg(-1), i.p.) administration followed by the assessment of locomotor activity, rearing activity and head bobs. Both doses of ondansetron attenuated cocaine's stimulatory effect on behaviours.3 Fluoxetine (0.05 or 5 mug) microinjected bilaterally into the core of the NAc 30 min before peripheral administration of cocaine produced dose-dependent biphasic effects on cocaine-induced behaviours. Intra-NAc administration of 0.05 mug fluoxetine resulted in a potentiation of cocaine-induced behaviours, while the higher dose of the SSRI (5 mug) attenuated the stimulant effect of cocaine on behaviours.4 To investigate a possible involvement of 5-HT3 receptors in fluoxetine'sfacilitatory action, ondansetron (10 ng) was microinjected 30 min prior tofluoxetine (0.05 mug), which resulted in a significant attenuation of the facilitatory effect of fluoxetine on cocaine-induced behaviours.5 Thus, 5-HT3 receptors in the core of the NAc appear to mediate stimulatory effects on cocaine induced locomotor activity, rears and head bobs, whereas the attenuation of cocaine-induced behaviours by fluoxetine at the higher dose. suggests the involvement of a different 5-HT receptor subtype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:18:08