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Titolo:
Weal and flare responses to intradermal rocuronium and cisatracurium in humans
Autore:
Levy, JH; Gottge, M; Szlam, F; Zaffer, R; McCall, C;
Indirizzi:
Emory Univ Hosp, Dept Anesthesiol, Atlanta, GA 30322 USA Emory Univ Hosp Atlanta GA USA 30322 t Anesthesiol, Atlanta, GA 30322 USA Emory Univ Hosp, Dept Dermatol, Atlanta, GA 30322 USA Emory Univ Hosp Atlanta GA USA 30322 Dept Dermatol, Atlanta, GA 30322 USA
Titolo Testata:
BRITISH JOURNAL OF ANAESTHESIA
fascicolo: 6, volume: 85, anno: 2000,
pagine: 844 - 849
SICI:
0007-0912(200012)85:6<844:WAFRTI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAPHYLACTOID REACTIONS; MUSCLE-RELAXANTS; ANESTHESIA; AGENTS; WHEAL;
Keywords:
neuromuscular block, rocuronium; neuromuscular block, cisatracurium; allergy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Levy, JH Emory Univ Hosp, Dept Anesthesiol, 1364 Clifton Rd NE, Atlanta, GA 30322 USA Emory Univ Hosp 1364 Clifton Rd NE Atlanta GA USA 30322 30322 USA
Citazione:
J.H. Levy et al., "Weal and flare responses to intradermal rocuronium and cisatracurium in humans", BR J ANAEST, 85(6), 2000, pp. 844-849

Abstract

Thirty volunteers underwent intradermal skin testing with increasing concentrations of rocuronium and cisatracurium to evaluate weal and flare responses, and whether either agent would cause mast cell degranulation and sensitization upon re-exposure. We found that intradermal injection of rocuronium and cisatracurium at concentrations > 10(4) M resulted in positive weal (> 8 mm) responses, and positive flare responses at >10(-4) and >10(-5) M respectively. Only cisatracurium caused mild to moderate mast cell degranulation, and neither drug caused significant in vitro histamine release from whole blood collected from study subjects 4 weeks after skin testing. Skin testing with rocuronium and cisatracurium should be performed at concentrations < 10(-4) and < 10(-5) M respectively to avoid false-positive responses. The ability of these agents to produce positive weal and flare responses atrelatively low concentrations may explain the high incidence of potential reactions reported.

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Documento generato il 20/01/21 alle ore 10:46:55