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Titolo:
Responses of rat subicular neurons to convergent stimulation of lateral entorhinal cortex and CA1 in vivo
Autore:
Gigg, J; Finch, DM; OMara, SM;
Indirizzi:
Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Psychol, Dublin 2, Ireland Univ Calif Los Angeles, Inst Brain Res, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 884, anno: 2000,
pagine: 35 - 50
SICI:
0006-8993(20001124)884:1-2<35:RORSNT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL AREA CA1; ELECTROPHYSIOLOGICALLY-DEFINED CLASSES; PYRAMIDAL CELLS-INVITRO; LONG-TERM POTENTIATION; IN-VITRO; SYNAPTIC TRANSMISSION; EFFERENT CONNECTIONS; VENTRAL SUBICULUM; ANATOMICAL DATA; ORGANIZATION;
Keywords:
morphology; immunohistochemistry; biocytin; pyramidal neuron; multipolar neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Gigg, J Univ Newcastle Upon Tyne, Dept Psychol, Ridley Bldg, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Univ Newcastle Upon Tyne Ridley Bldg Newcastle Upon Tyne Tyne & Wear England NE1 7RU
Citazione:
J. Gigg et al., "Responses of rat subicular neurons to convergent stimulation of lateral entorhinal cortex and CA1 in vivo", BRAIN RES, 884(1-2), 2000, pp. 35-50

Abstract

There has been Little electrophysiological examination of the afferent projection from lateral entorhinal cortex to dorsal subiculum. Here we provideevidence that synaptic inputs from lateral entorhinal cortex and CAI converge onto single dorsal subicular neurons in vivo. Subicular responses to CA1 stimulation consisted of excitation and/or long-duration inhibition. Neurons excited by CA1 activation usually showed inhibition to entorhinal stimulation. The latter inhibition was usually of short duration, however, long duration inhibition was seen in a significant proportion of responses. Entorhinal stimulation produced excitatory responses in four bursting cells andii was these cells that also tended to show the longest inhibition. Only bursting cells could be driven antidromically by entorhinal stimulation. Biocytin-filled multipolar and pyramidal cells displayed excitation-inhibitionsequences to CA1 and inhibition to entorhinal stimulation. These data strongly suggest that subicular inhibitory neurons receive excitatory input from CA1 and display mutual inhibition. The source of entorhinal-evoked inhibition is less clear. The relative sparseness of observed entorhinal-evoked responses suggests that the input to dorsal subiculum from any one part of lateral entorhinal cortex is spatially restricted. These data show that excitation-inhibition sequences can be seen in subicular pyramidal and multipolar cells and that single subicular neurons receive convergent inputs from CA1 and entorhinal cortex. We show for the first time that bursting cells can be driven both orthodromically and antidromically by direct entorhinal stimulation. These data support the existence of a reciprocal excitatory connection between lateral entorhinal cortex and dorsal subiculum and suggest further that this connection may involve only bursting subicular neurons. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:36:23