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Titolo:
Miniaturized real-time monitoring system for L-lactate and glucose using microfabricated multi-enzyme sensors
Autore:
Perdomo, J; Hinkers, H; Sundermeier, C; Seifert, W; Morell, OM; Knoll, M;
Indirizzi:
Inst Chemo & Biosensorik, D-48149 Muenster, Germany Inst Chemo & Biosensorik Muenster Germany D-48149 8149 Muenster, Germany Inst Super Politecn Jose A Echeverria, Ctr Invest Microelect, Havana 8, Cuba Inst Super Politecn Jose A Echeverria Havana Cuba 8 lect, Havana 8, Cuba Fachhsch Muenster, D-48565 Steinfurt, Germany Fachhsch Muenster Steinfurt Germany D-48565 , D-48565 Steinfurt, Germany
Titolo Testata:
BIOSENSORS & BIOELECTRONICS
fascicolo: 9-10, volume: 15, anno: 2000,
pagine: 515 - 522
SICI:
0956-5663(200011)15:9-10<515:MRMSFL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICRODIALYSIS SYSTEM; TECHNOLOGY; BLOOD;
Keywords:
lactate sensor; glucose sensor; containment technology; microdialysis sampling; miniaturization; silicon technology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Hinkers, H Inst Chemo & Biosensorik, Mendelstr 7, D-48149 Muenster, Germany Inst Chemo & Biosensorik Mendelstr 7 Muenster Germany D-48149
Citazione:
J. Perdomo et al., "Miniaturized real-time monitoring system for L-lactate and glucose using microfabricated multi-enzyme sensors", BIOSENS BIO, 15(9-10), 2000, pp. 515-522

Abstract

A miniaturized on-line monitoring system for the detection of L-lactate and glucose is presented. The system is based on a microfabricated multi-enzyme silicon sensor chip with flow channels integrated on the chip. The sensors were fabricated in containment technology. They were characterized in test solutions. The cross-talking behaviour was investigated and was found tobe practically negligible. The linear measurement ranges of both glucose and lactate sensors were large enough for most practical applications. As a result of the miniaturization the analyte consumption could be reduced to afew nmol min(-1). The system was equipped with a microdialysis probe whoserecovery was 45% for lactate and 37% for glucose in test solutions using aflow rate of 3 mul min(-1). Lower flow rates of 0.5 mul min(-1) resulted in recoveries of over 90%. The long-term stability of the system was acceptable. Initial measurements have also been performed in vitro using human blood serum. (C) 2000 Elsevier Science S.A. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:17:39