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Titolo:
Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: Tandem linkage with the minor histocompatibility antigen HA-1 gene
Autore:
Kaminski, WE; Piehler, A; Schmitz, G;
Indirizzi:
Univ Regensburg, Inst Clin Chem & Lab Med, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 278, anno: 2000,
pagine: 782 - 789
SICI:
0006-291X(20001130)278:3<782:GOOTHC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING CASSETTE TRANSPORTER-1; VERSUS-HOST DISEASE; TANGIER-DISEASE; MARROW TRANSPLANTATION; PROTEINS; PROMOTER; DONORS; IDENTIFICATION; EXPRESSION; INVENTORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitz, G Univ Regensburg, Inst Clin Chem & Lab Med, Franz Josef Str Allee 11, D-93042 Regensburg, Germany Univ Regensburg Franz Josef Str Allee 11 Regensburg Germany D-93042
Citazione:
W.E. Kaminski et al., "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: Tandem linkage with the minor histocompatibility antigen HA-1 gene", BIOC BIOP R, 278(3), 2000, pp. 782-789

Abstract

We have recently cloned a novel cholesterol-responsive ABC transporter, designated ABCA7, which is predominantly expressed in human leukocytes. Here we report the structure of the human ABCA7 gene. The ABCA7 gene spans a region of similar to 32 kb and comprises 46 exons. Its putative promoter sequence contains potential binding sites for transcription factors with roles in hematopoiesis and cholesterol metabolism. Surprisingly, sequence analysisof the ABCA7 3' gene flanking region revealed that the terminal exon of ABCA7 borders immediately on the 5' end of the coding region of the recently identified human minor histocompatibility antigen HA-1. We demonstrate thatthe coding regions of ABCA7 and HA-1 are physically separated by a 1.7-kb intergene region. Subsequent genomic structure analysis showed that the HA-1 gene consists of 23 exons which extend across a 16-kb genomic region. Ourresults provide evidence that the genes for the human minor histocompatibility antigen HA-1 and the ABC transporter ABCA7 are arranged in a head-to-tail array and that both genes localize to a common locus of similar to 48 kb size on chromosome 19p13.3. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:51:27