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Titolo:
Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene
Autore:
Foussias, G; Yousef, GM; Diamandis, EP;
Indirizzi:
Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada Mt SinaiHosp Toronto ON Canada M5G 1X5 Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada Lab Med & Pathobiol, Toronto, ON, Canada
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 278, anno: 2000,
pagine: 775 - 781
SICI:
0006-291X(20001130)278:3<775:MCOASV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN-ASSOCIATED GLYCOPROTEIN; IMMUNOGLOBULIN-LIKE DOMAINS; ACID-BINDING-RECEPTOR; NATURAL-KILLER-CELLS; INHIBITORY RECEPTOR; MESSENGER-RNA; CDNA CLONING; SIALOADHESIN; PROTEIN; CD33;
Keywords:
siglec gene family; CD33-like subgroup; immunoglobulin superfamily; sialoadhesins; immunoreceptor tyrosine kinase inhibition motif (ITIM); alternative splicing; gene mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Diamandis, EP Mt Sinai Hosp, Dept Pathol & Lab Med, 600 Univ Ave, Toronto,ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave Toronto ON Canada M5G 1X5 Canada
Citazione:
G. Foussias et al., "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene", BIOC BIOP R, 278(3), 2000, pp. 775-781

Abstract

Through efforts to investigate the CD33-like subgroup of sialic acid binding immunoglobulin-like lectins (Siglecs), which are believed to be located on chromosome 19q13.4, we have identified the precise genomic region containing the Siglecs gene, It is located on chromosome 19q13.4, approximately 330 kb downstream of the Siglec9 gene. Further, we have identified a novel Siglec8 variant, named Siglec8-Long (Siglec8-L), which differs in its last two exons from the previously published mRNA sequence of Siglec8 (Gen-Bank Accession No. AF195092). Both Siglec8 and Siglec8-L are comprised of seven exons, of which the first five are identical, followed by marked differencesin exon usage and mRNA splicing, The 499 amino acid protein encoded by theSiglec8-L open reading frame has a molecular weight of 54 kDa, Like the other members of the CD33-like subgroup of Siglecs, except for the previouslypublished Siglecs, Siglec8-L also contains the two tyrosine-based motifs that have been found to recruit both SH2 domain-containing tyrosine and inositol phosphatases, (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:37:02