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Titolo:
Alteration in the hypothalamic-pituitary-ovarian axis in depressed women
Autore:
Young, EA; Midgley, AR; Carlson, NE; Brown, MB;
Indirizzi:
Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Michigan, Reprod Sci Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Sci Program, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Biostat, Ann Arbor, MI 48109 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 12, volume: 57, anno: 2000,
pagine: 1157 - 1162
SICI:
0003-990X(200012)57:12<1157:AITHAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; PSYCHIATRIC-DISORDERS; CORTISOL SECRETION; RHESUS-MONKEY; LH-SECRETION; SHORT-TERM; CORTICOTROPIN; AMENORRHEA; PREVALENCE; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Young, EA Univ Michigan, Mental Hlth Res Inst, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 USA Univ Michigan 205 Zina Pitcher Pl Ann Arbor MI USA 48109 109 USA
Citazione:
E.A. Young et al., "Alteration in the hypothalamic-pituitary-ovarian axis in depressed women", ARCH G PSYC, 57(12), 2000, pp. 1157-1162

Abstract

Background: Stress and corticotropin-releasing hormone inhibit the reproductive axis. We hypothesized that reproductive axis hormone secretion, particularly luteinizing hormone secretion, is inhibited in women with depression, similar to what has been observed to be caused by stress in numerous species. Methods: Blood samples were collected every 10 minutes for 12 hours in 25 untreated premenopausal women with depression and 25 nondepressed women whowere matched by age and menstrual cycle day. Samples were assayed for luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone. Results: The mean plasma estradiol level was 30% lower in the follicular phase in women with depression than in their matched controls: 191+/-136 vs 261+/-169 pmol/L (52 +/- 37 vs 71 +/- 46 pg/mL). The half-life of luteinizing hormone was significantly shorter in women with depression than in theirmatched controls during both the follicular (22% shorter) and luteal (15% shorter) phases. Conclusions: The blood levels of reproductive hormones were mostly normal in women with depression, but the blood level of estradiol was significantly lower. Estradiol is known to affect a number of neurotransmitter systems in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:21:36