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Titolo:
Neurochemical individuality - Genetic diversity among human dopamine and serotonin receptors and transporters
Autore:
Cravchik, A; Goldman, D;
Indirizzi:
Celera Genom, Rockville, MD 20850 USA Celera Genom Rockville MD USA 20850Celera Genom, Rockville, MD 20850 USA NIAAA, Neurogenet Lab, NIH, Bethesda, MD USA NIAAA Bethesda MD USANIAAA, Neurogenet Lab, NIH, Bethesda, MD USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 12, volume: 57, anno: 2000,
pagine: 1105 - 1114
SICI:
0003-990X(200012)57:12<1105:NI-GDA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-NUCLEOTIDE POLYMORPHISMS; DEFICIT HYPERACTIVITY DISORDER; AMINO-ACID SUBSTITUTIONS; DRD2 VARIANT SER311CYS; HUMAN 5-HT1A RECEPTOR; MICE LACKING; NOVELTY SEEKING; MUTANT MICE; ANOREXIA-NERVOSA; D2 RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Cravchik, A Celera Genom, 45 W Gude Dr, Rockville, MD 20850 USA Celera Genom 45 W Gude Dr Rockville MD USA 20850 MD 20850 USA
Citazione:
A. Cravchik e D. Goldman, "Neurochemical individuality - Genetic diversity among human dopamine and serotonin receptors and transporters", ARCH G PSYC, 57(12), 2000, pp. 1105-1114

Abstract

Behavioral variation in human beings encompasses wide differences in personality and susceptibility to psychiatric illness arising from both genotypeand experience. Longlasting behavioral differences generally have heritabilities of 30% or more, and such inheritance is ultimately attributable to functional variants of genes programming brain development and function. Thesequencing of the human genome is revealing a pattern of gene sequence variation. The ability of sequence variants to affect neural function either alone or in concert may reveal effects of behavioral selection on the human genome over evolutionary time frames. Dopamine and serotonin are phylogenetically ancient neurotransmitters intrinsic to brain function and behavior. Dopamine and serotonin receptor and transporter genes have been an early focus for efforts to identify and functionally characterize sequence variation. The purpose of this article is to present a preview of a developing new perspective in human behavior: the genetic variation of the brain or neurochemical individuality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:02:13