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Titolo:
Radiosynthesis of [I-123]beta CIT, a selective ligand for the study of thedopaminergic and serotoninergic systems in human brain
Autore:
Carpinelli, A; Matarrese, M; Moresco, RM; Simonelli, P; Todde, S; Magni, F; Kienle, MG; Fazio, F;
Indirizzi:
Univ Milan, CNR, INB, Sci Inst H San Raffaele, I-20132 Milan, Italy Univ Milan Milan Italy I-20132 Inst H San Raffaele, I-20132 Milan, Italy
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 1, volume: 54, anno: 2001,
pagine: 93 - 95
SICI:
0969-8043(200101)54:1<93:RO[CAS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON EMISSION TOMOGRAPHY; BETA-CIT; NONHUMAN-PRIMATES; TRANSPORTERS; 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE; DISEASE;
Keywords:
[I-123]beta CIT; SPECT; radiosynthesis; human brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Fazio, F Univ Milan, CNR, INB, Sci Inst H San Raffaele, Via Olgettina 58, I-20132 Milan, Italy Univ Milan Via Olgettina 58 Milan Italy I-20132 132 Milan, Italy
Citazione:
A. Carpinelli et al., "Radiosynthesis of [I-123]beta CIT, a selective ligand for the study of thedopaminergic and serotoninergic systems in human brain", APPL RAD IS, 54(1), 2001, pp. 93-95

Abstract

The procedure previously reported for the radiosynthesis of [I-123]beta CIT was modified in order to improve both radiochemical yield and purity of beta CIT (2 beta -carbomethoxy-3 beta (4-iodophenyl) tropane) to be injectedfor SPECT (Single Photon Emission Computed Tomography) analysis imaging. The overall procedure, involving a HPLC purification step, results in quite good and reproducible yields of a highly purified tracer. (C) 2000 ElsevierScience Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:52:27