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Titolo:
Antitumoral effects of an intravesically applied aqueous mistletoe extracton urinary bladder carcinoma MB49 in mice
Autore:
Mengs, U; Schwarz, T; Bulitta, M; Weber, K;
Indirizzi:
Madaus AG, D-51109 Cologne, Germany Madaus AG Cologne Germany D-51109Madaus AG, D-51109 Cologne, Germany RCC Ltd, CH-4452 Itingen, Switzerland RCC Ltd Itingen Switzerland CH-4452 CC Ltd, CH-4452 Itingen, Switzerland
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5B, volume: 20, anno: 2000,
pagine: 3565 - 3568
SICI:
0250-7005(200009/10)20:5B<3565:AEOAIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSIDE-SPECIFIC LECTIN; BACILLUS-CALMETTE-GUERIN; VISCUM-ALBUM; IN-VITRO; CANCER; THERAPY; CYTOTOXICITY; LYMPHOCYTES; APOPTOSIS; INDUCTION;
Keywords:
mistletoe extract; mistletoe lectin; urinary bladder carcinoma; MB 49 model; mouse; antitumoral activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mengs, U Madaus AG, Ostmerheimer Str 198, D-51109 Cologne, Germany Madaus AG Ostmerheimer Str 198 Cologne Germany D-51109 , Germany
Citazione:
U. Mengs et al., "Antitumoral effects of an intravesically applied aqueous mistletoe extracton urinary bladder carcinoma MB49 in mice", ANTICANC R, 20(5B), 2000, pp. 3565-3568

Abstract

The objective of the present study was to investigate the effects of a locally applied aqueous mistletoe extract (AME) on the growth of urinary bladder carcinoma MB49 in an orthotopic murine model. On day 1, a total of 4x10(4) tumor cells was implanted into the bladder of female C57BL/6J mice. The animals were then randomly allocated to three groups of 13 mice each. A om day II onwards, AME was given intravesically 3 days a week for 4 consecutive weeks at concentrations related to 30 or 300 ng bioactive mistletoe lectin (ML)/ml. The animals received a total volume of 0.1 ml In the control group, 39% of the mice survived to the end of the scheduled study period in comparison to 69% and 85% in the goups treated with 30 ol 300 ng ML/ml, respectively At necropsy, 80% of the surviving control animals showed a visible solid bladder tumor, whereas only 56% and 18% had tumors in the treated groups. lit both cases, the differences were statistically significant at the high concentration in comparison to controls (p < 0.05). A nonsignificant effect was observed regarding the formation of multiple metastases (40% in controls vs 33% and 18% in the treated groups). A om the results, it was concluded that under the conditions described, AME shows antitumoral activity which is considered to be mainly due to the cytotoxic propel-ties of mistletoe lectins, the main effective constituents of mistletoe extracts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:33:54