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Titolo:
Expression of myeloperoxidase in the inner ear of cisplatin-treated guineapigs
Autore:
Watanabe, K; Yagi, T;
Indirizzi:
Nippon Med Sch, Dept Otorhinolaryngol, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 ngol, Bunkyo Ku, Tokyo 1138603, Japan
Titolo Testata:
ANTI-CANCER DRUGS
fascicolo: 9, volume: 11, anno: 2000,
pagine: 727 - 730
SICI:
0959-4973(200010)11:9<727:EOMITI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIS-DIAMMINEDICHLOROPLATINUM; POLYMORPHONUCLEAR LEUKOCYTES; INDUCED TOXICITY; NITRIC-OXIDE; OTOTOXICITY; GENERATION; AGENTS; SYSTEM;
Keywords:
cisplatin; immunohistochemistry; inner ear dysfunction; myeloperoxidase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, K Nippon Med Sch, Dept Otorhinolaryngol, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan Nippon Med Sch 1-1-5 Sendagi Tokyo Japan 1138603 38603, Japan
Citazione:
K. Watanabe e T. Yagi, "Expression of myeloperoxidase in the inner ear of cisplatin-treated guineapigs", ANTI-CANC D, 11(9), 2000, pp. 727-730

Abstract

Cisplatin is known to cause inner ear damage (ototoxicity). The role of myeloperoxidase (MPO) in the inner ear of the guinea pigs after injections ofcisplatin i.p. was examined immunohistochemically. Three days after the injection, the animals were sacrificed with intracardiac perfusion of fixative, and temporal bones were removed and processed for immunohistochemistry with the anti-MPO antibody. MPO could be detected after 3 days in the lateral wall, the organ of Corti, supporting cells of the sensory epithelium and dark cells. These results suggest that MPO and reactive oxygen species are involved in the inner ear dysfunction after the application of cispiatin. [(C) 2000 Lippincott Williams & Wilkins].

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:39:29