Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Specific c-K-ras gene mutations as a tumor-response marker in locally advanced rectal cancer treated with preoperative chemoradiotherapy
Autore:
Luna-Perez, P; Segura, J; Alvarado, I; Labastida, S; Santiago-Payan, H; Quintero, A;
Indirizzi:
Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Oncol, Colorectal Serv, Mexico City 06760, DF, Mexico Inst Mexicano Seguro Social Mexico City DF Mexico 06760 06760, DF, Mexico Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Oncol, Dept SurgOncol, Mexico City, DF, Mexico Inst Mexicano Seguro Social Mexico City DF Mexico exico City, DF, Mexico Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Oncol, Dept Pathol, Mexico City, DF, Mexico Inst Mexicano Seguro Social Mexico City DF Mexico exico City, DF, Mexico Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Oncol, Stat Sect, Mexico City, DF, Mexico Inst Mexicano Seguro Social Mexico City DF Mexico exico City, DF, Mexico Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico
Titolo Testata:
ANNALS OF SURGICAL ONCOLOGY
fascicolo: 10, volume: 7, anno: 2000,
pagine: 727 - 731
SICI:
1068-9265(200012)7:10<727:SCGMAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER; PROGNOSTIC-SIGNIFICANCE; HUMAN-COLON; ADENOCARCINOMA; TUMORIGENESIS; CARCINOMA; OVEREXPRESSION; SURVIVAL; SURGERY;
Keywords:
K-ras; tumor markers; rectal cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Luna-Perez, P Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Oncol, Colorectal Serv, Puerto Mexico 53-101,Colonia Roma, Mexico City 06760,DF, Mexico Inst Mexicano Seguro Social Puerto Mexico 53-101,Colonia Roma Mexico City DF Mexico 06760
Citazione:
P. Luna-Perez et al., "Specific c-K-ras gene mutations as a tumor-response marker in locally advanced rectal cancer treated with preoperative chemoradiotherapy", ANN SURG O, 7(10), 2000, pp. 727-731

Abstract

Background: Forty percent of patients with colorectal cancer develop mutations in the K-ras gene. Objective: Our objective was to evaluate whether the presence of c-K-ras gene mutations is a useful tumor-response marker in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy. Material and Methods: Thirty seven patients with locally advanced rectal cancer were treated with preoperative chemoradiotherapy. Four to six weeks later, surgery was performed. Specimens were classified according to the UICC-AJC classification, ii segment of the tumor was obtained to analyze specific c-g-ras gene mutations. Restriction fragment length polymorphism (RFLP)and single strand confirmation polymorphism (SSCP) techniques were used with a set of probes to detect specific c-K-ras mutations in codons 12, 13, and 61. The 37 patients were divided into Group A (with mutations) and GroupB (without mutations). Results: All 37 patients completed the scheduled treatment. Group A consisted of 12 patients, whose tumors were classified and specific c-K-ras mutations were located as follows: eight in codon 12, two in codon 13, and one in codon 61. Group B consisted of 25 patients. The tumors were classified and there were more early-stage tumors in Group A, whereas in Group B there were more advanced-stage tumors (P = .05, respectively). The mean follow-up was 36.2 +/- 18.3 months. All Group A patients survived, whereas 8 of the 25 patients in Group B died due to progressive metastatic disease. Survival in Group A was 100%, whereas in Group B it was 59% (P = .03). Conclusions: The presence of specific c-g-ras mutations is an indicator oftumor response in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy and surgery. Therefore, responding patients may be more amenable to less radical surgical procedures based on c-K-rasmutations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:22:14