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Titolo:
Failure to replicate an association between the catechol-O-methyltransferase polymorphism and attention deficit hyperactivity disorder in a second, independently recruited Israeli cohort
Autore:
Manor, I; Kotler, M; Sever, Y; Eisenberg, J; Cohen, H; Ebstein, RP; Tyano, S;
Indirizzi:
S Herzog Mem Hosp, Res Lab, IL-91351 Jerusalem, Israel S Herzog Mem Hosp Jerusalem Israel IL-91351 , IL-91351 Jerusalem, Israel Geha Mental Hlth Ctr, Petah Tiqwa, Israel Geha Mental Hlth Ctr Petah Tiqwa Israel l Hlth Ctr, Petah Tiqwa, Israel Ben Gurion Univ Negev, Fac Hlth Sci, Beersheva Mental Hlth Ctr, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel S Herzog Mem Hosp, Child Psychiat Clin, IL-91351 Jerusalem, Israel S Herzog Mem Hosp Jerusalem Israel IL-91351 , IL-91351 Jerusalem, Israel
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 6, volume: 96, anno: 2000,
pagine: 858 - 860
SICI:
0148-7299(200012)96:6<858:FTRAAB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAPLOTYPE RELATIVE RISK; BEHAVIOR; ALLELE; COMT;
Keywords:
attention deficit hyperactivity disorder (ADHD); catechol-O-methyltransferase (COMT); polymorphism; association; haplotype relative risk; complex genetic disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Eisenberg, J S Herzog Mem Hosp, Res Lab, POB 35300, IL-91351 Jerusalem, Israel S Herzog Mem Hosp POB 35300 Jerusalem Israel IL-91351 Israel
Citazione:
I. Manor et al., "Failure to replicate an association between the catechol-O-methyltransferase polymorphism and attention deficit hyperactivity disorder in a second, independently recruited Israeli cohort", AM J MED G, 96(6), 2000, pp. 858-860

Abstract

Attention deficit hyperactivity disorder (ADHD) is a developmental syndrome expressed along three domains: inattention, hyperactive-impulsive, and combined type, Both environmental and genetic factors contribute to the etiology of this complex disease. We previously reported an association in 48 ADHD triads (both parents and proband) between the catechol-O-methyltransferase (COMT) polymorphism (especially the high enzyme activity val allele) andthe Diagnostic and Statistical Manual of Mental Disorders (DSM IV) combined category (excluding inattention) of ADHD (however, see erratum, Am. J. Med. Genet, [Neuropsychiatr. Genet.] 96:000). In the current report, we attempted to replicate this finding in an independently recruited group of 70 nuclear families using the haplotype relative risk design. In the current investigation, no evidence for association of the COMT polymorphism and ADHD (or any of the DSM ni subtypes) was observed in either the current cohort orthe expanded cohort of 118 Israeli triads. (C) 2000 Wiley-Liss Inc.

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Documento generato il 04/04/20 alle ore 02:23:36