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Titolo:
Search for bipolar disorder susceptibility loci: The application of a modified genome scan concentrating on gene-rich regions
Autore:
Murphy, VE; Mynett-Johnson, LA; Claffey, E; Bergin, P; McAuliffe, M; Kealey, C; McKeon, P;
Indirizzi:
Univ Dublin Trinity Coll, Smurfit Inst Genet, Dept Genet, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 Dept Genet, Dublin 2, Ireland Univ Dublin Trinity Coll, Dept Psychiat, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 pt Psychiat, Dublin 2, Ireland St Patricks Hosp, Depress Res Unit, Dublin, Ireland St Patricks Hosp Dublin Ireland Hosp, Depress Res Unit, Dublin, Ireland
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 6, volume: 96, anno: 2000,
pagine: 728 - 732
SICI:
0148-7299(200012)96:6<728:SFBDSL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; WIDE SEARCH; LINKAGE ANALYSIS; PEDIGREES; ILLNESS; CHROMOSOME-15; INTELLIGENT; TRAITS; MAP;
Keywords:
manic depression; sib-pairs; serotonin transporter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mynett-Johnson, LA Univ Dublin Trinity Coll, Smurfit Inst Genet, Dept Genet, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 2, Ireland
Citazione:
V.E. Murphy et al., "Search for bipolar disorder susceptibility loci: The application of a modified genome scan concentrating on gene-rich regions", AM J MED G, 96(6), 2000, pp. 728-732

Abstract

Conducting genome wide screens for evidence of genetic linkage has become a well-established method for identifying regions of the human genome harboring susceptibility loci for complex disorders. For bipolar disorder, a number of such studies have been performed, and several regions of the genome have potentially been implicated in the disorder. The classic design for a genome screen involves examining polymorphic genetic markers spaced at regular intervals throughout the genome, typically every 10 cM for evidence of linkage. An alternative design, based on the observation that genes do not appear to be evenly distributed, was proposed, enabling the number of markers examined in a genome wide screen to be reduced. This article describes the application of such a modified screen to a collection of 48 Irish families with bipolar disorder, comprising a total of 82 affected sib-pairs. Fromthe results obtained a number of regions are highlighted for further study. One of these regions (17q11.1-q12) coincides with the location of a candidate gene, the serotonin transporter, whereas others concur with the findings of published studies. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:47:50