Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association between blood pressure reduction with antihypertensive treatment and sleep apnea activity
Autore:
Grote, L; Wutkewicz, K; Knaack, L; Ploch, T; Hedner, J; Peter, JH;
Indirizzi:
Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Univ Marburg Klinikum, Med Poliklin, Marburg, Germany Univ Marburg Klinikum Marburg Germany m, Med Poliklin, Marburg, Germany Sahlgrens Univ Hosp, Sleep Lab, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 12, volume: 13, anno: 2000,
pagine: 1280 - 1287
SICI:
0895-7061(200012)13:12<1280:ABBPRW>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK FACTOR; HYPERTENSION; THERAPY; HUMANS; HEMODYNAMICS; PULMONARY; RATS;
Keywords:
sleep apnea; hypertension; antihypertensive agents; drug treatment; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Grote, L Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 othenburg, Sweden
Citazione:
L. Grote et al., "Association between blood pressure reduction with antihypertensive treatment and sleep apnea activity", AM J HYPERT, 13(12), 2000, pp. 1280-1287

Abstract

This study investigated whether a drug therapy-induced reduction in nocturnal blood pressure (BP) was associated with decreased sleep apnea activity. Two polysomnographies from 54 hospitalized male hypertensive, obstructive sleep apnea patients were analyzed in a double-blind, randomized, parallel-group trial of the angiotensin-converting enzyme inhibitor cilazapril (C), 2.5 mg once daily, or placebo (P). Blood pressure was measured by means of an intra-arterial catheter. Compared with P, C lowered mean arterial BP during non-rapid eye movement (NREM) (-8.3 +/- 10.7 mm Hg, P =.05) and REM sleep (-8.6 +/- 10.1 mn Hg, P =.02). Respiratory disturbance index (-8.6 +/- 3.2 events/h of sleep (n/h), P =.01) and apnea index (AI) (-6.6 +/- 3.0 n/h,P =.04) during NREM sleep were lowered by C and, to a lesser extent, by P (-5.9 +/- 3.2 n/h, P =.07 and -5.0 +/- 3.6 n/h, P =.18, respectively). The effect on AI and hypopnea index (KI) during REM sleep was not significant for C (-5.9 +/- 3.4 and 0.1 +/- 2.0, NS, respectively) and P (-2.6 +/- 3.9 and 1.6 +/- 2.0, NS, respectively). There was a significant linear correlation between the change in REM systolic BP and the change in REM Al (r = 0.28, P =.04); the mean BP change correlated negatively with the change in HI (-0.28, P =,04). During NREM sleep there was no significant correlation between changes in BP and the treatment effects on sleep apnea activity. Blood pressure reduction after short-term antihypertensive treatment did not affect sleep disordered breathing during NREM sleep. Reduced BP was associated with a weak reduction of AI and a slight increase of HI during REM sleep. It appears that elevated BP contributes only marginally to sleep apnea severity in hypertensive patients with obstructive sleep apnea. Am J Hypertens 2000;13:1280-1287 (C) 2000 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:07:25