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Titolo:
X-ray crystal structure analysis of substituted 5-(2,3-dihydro-7-benzofuryl)-2-methylpyrazolo [4,3-d]pyrimidin-7-one (iso-Biagra)
Autore:
El-Abadelah, MM; Sabri, SS; Khanfar, MA; Voelter, W; Maichle-Mossmer, C;
Indirizzi:
Univ Tubingen, Inst Physiol Chem, Phys Biochem Abt, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 em Abt, D-72076 Tubingen, Germany Univ Tubingen, Inst Anorgan Chem, D-72076 Tubingen, Germany Univ TubingenTubingen Germany D-72076 n Chem, D-72076 Tubingen, Germany Univ Jordan, Fac Sci, Dept Chem, Amman, Jordan Univ Jordan Amman JordanUniv Jordan, Fac Sci, Dept Chem, Amman, Jordan
Titolo Testata:
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
fascicolo: 11, volume: 55, anno: 2000,
pagine: 1079 - 1082
SICI:
0932-0776(200011)55:11<1079:XCSAOS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-5 CGMP PHOSPHODIESTERASE; SILDENAFIL; PHYSIOLOGY; INHIBITOR; ERECTION;
Keywords:
2-methylpyrazolo[4,3-d]pyrimidin-7-one; dihydrobenzofuran derivative;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Voelter, W Univ Tubingen, Inst Physiol Chem, Phys Biochem Abt, Hoppe Seyler Str 4, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 4 Tubingen Germany D-72076 many
Citazione:
M.M. El-Abadelah et al., "X-ray crystal structure analysis of substituted 5-(2,3-dihydro-7-benzofuryl)-2-methylpyrazolo [4,3-d]pyrimidin-7-one (iso-Biagra)", Z NATURFO B, 55(11), 2000, pp. 1079-1082

Abstract

X-ray crystal structure data for the substituted 5-(2,3-dihydro-7-benzofuryl)-2-methylpyrazolo[4,3-d]pyrimidin-7-one (3) reveal that the two bicyclicheteroaryl systems show no coplanarity along their joint C(5)-C(ll) axis with an interplanar angle of 9.6 degrees. Nonetheless, the spatial interatomic distance for O(17)-N(6), determined as 2.73 Angstrom, allows the formation of a relatively weak intramolecular hydrogen bond between the pyrimidinone N(6)-H and the O(17) lone pair of the dihydrobenzofuryl moiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/08/20 alle ore 02:47:53