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Titolo:
Actin assembly at membranes controlled by ARF6
Autore:
Schafer, DA; DSouza-Schorey, C; Cooper, JA;
Indirizzi:
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ St Louis MO USA 63110 l & Physiol, St Louis, MO 63110 USA Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA Univ Notre Dame Notre Dame IN USA 46556 iol Sci, Notre Dame, IN 46556 USA Walther Canc Inst, Notre Dame, IN 46556 USA Walther Canc Inst Notre Dame IN USA 46556 Inst, Notre Dame, IN 46556 USA
Titolo Testata:
TRAFFIC
fascicolo: 11, volume: 1, anno: 2000,
pagine: 892 - 903
SICI:
1398-9219(200011)1:11<892:AAAMCB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADP-RIBOSYLATION FACTOR; NUCLEOTIDE EXCHANGE FACTOR; ALDRICH-SYNDROME PROTEIN; PHOSPHOLIPASE-D; ARP2/3 COMPLEX; CYTOSKELETAL REARRANGEMENTS; HUMAN-NEUTROPHILS; PLASMA-MEMBRANE; VESICULAR TRANSPORT; SHAPE CHANGES;
Keywords:
actin assembly; actin dynamics; ARF6; pinocytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Cooper, JA Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 , St Louis, MO 63110 USA
Citazione:
D.A. Schafer et al., "Actin assembly at membranes controlled by ARF6", TRAFFIC, 1(11), 2000, pp. 892-903

Abstract

The small GTPase, ADP-ribosylation factor-6 (ARF6), has been implicated inregulating membrane traffic and remodeling cortical F-actin. Using real-time video analysis of actin assembly in living cells, we investigated the function and mechanism of ARF6 in control of actin assembly. Expression of anactivated form of ARF6 that mimicks the GTP-bound form of the GTPase induced actin assembly resulting in the movement of vesicle-like particles, someof which contain markers for pinosomes. Activated ARF6 also stimulated actin assembly at foci on the ventral surface of the cell and stimulated fluidphase pinocytosis, Particle motility induced by ARF6 involved Arp2/3 complex, tyrosine kinase activity, phospholipase D (PLD) and D3-phosphoinositides. but not phosphatidylinositol 4,5-bisphosphate (PI(4,5)P-2). We conclude that ARF6 regulates actin assembly for pinosome motility and at foci on theventral cell surface.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:20:22