Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Suspended particulate matter in indoor air: adjuvants and allergen carriers
Autore:
Ormstad, H;
Indirizzi:
Natl Publ Hlth Inst, Dept Environm Med, N-0403 Oslo, Norway Natl Publ HlthInst Oslo Norway N-0403 Environm Med, N-0403 Oslo, Norway
Titolo Testata:
TOXICOLOGY
fascicolo: 1-3, volume: 152, anno: 2000,
pagine: 53 - 68
SICI:
0300-483X(20001102)152:1-3<53:SPMIIA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIESEL EXHAUST PARTICLES; FEL-D-I; IGE ANTIBODY-PRODUCTION; GRASS-POLLEN ALLERGEN; HOUSE-DUST PARTICLES; MAJOR DOG ALLERGEN; CAT ALLERGEN; BIRCH POLLEN; COCKROACH ALLERGENS; RESPIRATORY-DISEASE;
Keywords:
house dust; allergens; adjuvant; particles; indoor; SPM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Ormstad, H Natl Publ Hlth Inst, Dept Environm Med, POB 4404,Torshov, N-0403 Oslo, Norway Natl Publ Hlth Inst POB 4404,Torshov Oslo Norway N-0403 Norway
Citazione:
H. Ormstad, "Suspended particulate matter in indoor air: adjuvants and allergen carriers", TOXICOLOGY, 152(1-3), 2000, pp. 53-68

Abstract

The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM)with regard to amount, as well as elemental and size distribution, second,to identify possible mechanisms by which SPM may affect the allergic immune response. A vast majority of the particles in SPM samples from homes in Oslo were found to be less than 2.5 mum in diameter. This PM2.5 fraction contained, in addition to a large amount of sulfur aerosols and silicates, a lot of soot particles. Most of these were less than I mum in diameter. Usingan immunogold labeling technique, we found that these soot particles carried cat, dog and birch allergens on their surface. These results show that indoor SPM contains a lot of potential allergen carriers, i.e. soot particles (carbon aggregates), most of them less that 1 mum in diameter and therefore able to transport allergens deep into the respiratory tree. We further found that diesel exhaust particles (DEP), which is likely the main soot component of SPM, adsorbed several well-known allergens in vitro. Furthermore,SPM was found to elicit a local lymph node inflammatory response, and to have an adjuvant activity on the production of IgE antibodies to ovalbumin (OA). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:20:56