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Titolo:
Cardiovascular risk factors in vegetarians: Normalization of hyperhomocysteinemia with vitamin B-12 and reduction of platelet aggregation with n-3 fatty acids
Autore:
Mezzano, D; Kosiel, K; Martinez, C; Cuevas, A; Panes, O; Aranda, E; Strobel, P; Perez, DD; Pereira, J; Rozowski, J; Leighton, F;
Indirizzi:
Catholic Univ Chile, Sch Med, Dept Hematol Oncol, Santiago, Chile CatholicUniv Chile Santiago Chile Dept Hematol Oncol, Santiago, Chile Catholic Univ Chile, Sch Med, Dept Nutr Diabet & Metab, Santiago, Chile Catholic Univ Chile Santiago Chile Nutr Diabet & Metab, Santiago, Chile Catholic Univ Chile, Fac Biol Sci, Dept Cell Biol, Santiago, Chile Catholic Univ Chile Santiago Chile Sci, Dept Cell Biol, Santiago, Chile
Titolo Testata:
THROMBOSIS RESEARCH
fascicolo: 3, volume: 100, anno: 2000,
pagine: 153 - 160
SICI:
0049-3848(20001101)100:3<153:CRFIVN>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; COD-LIVER OIL; DOCOSAHEXAENOIC ACID; COBALAMIN DEFICIENCY; PLASMA HOMOCYSTEINE; BLEEDING-TIME; EICOSAPENTAENOIC ACID; FISH CONSUMPTION; SERUM-LIPIDS; DIET;
Keywords:
vegetarians; vitamin B-12 deficiency; hyperhomocysteinemia; n-3 fatty acids; platelet aggregation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Mezzano, D Catholic Univ Chile, Sch Med, Dept Hematol Oncol, POB 114D, Santiago, Chile Catholic Univ Chile POB 114D Santiago Chile , Santiago, Chile
Citazione:
D. Mezzano et al., "Cardiovascular risk factors in vegetarians: Normalization of hyperhomocysteinemia with vitamin B-12 and reduction of platelet aggregation with n-3 fatty acids", THROMB RES, 100(3), 2000, pp. 153-160

Abstract

Hyperhomocysteinemia in association with vitamin B-12 deficiency, and increased platelet aggregation, probably due to dietary lack of n-3 fatty acids, constitute cardiovascular risk factors frequently observed in vegetarians. We tested if administration of vitamin B-12 normalizes the concentration of total plasma homocysteine, and if intake of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) fatty acids modulates platelet function in a population of lactoovovegetarians. One week after a single intramuscular injection of cyanocobalamin (10000 mug) in 18 individuals, serum vitamin B-12 increased from 149+/-63 pg/mL to 532+/-204 pg/mL (p<0.0001) and total tHcy dropped from 12.4+/-4.7 to 7.9+/-3.1 <mu>mol/L (p<0.0001). Ten of fourteen of these vegetarians completed an 8-week supplementation with 700 mg/day ofeach eicosapentaenoic and docosahexaenoic acids. Increased incorporation of these fatty acids into plasma lipids was observed in all of them, together with a significant reduction in maximum percentage or slope of platelet aggregation with all the agonists tested (ADP, epinephrin, collagen, arachidonic acid). No significant change in bleeding time was observed after n-3 fatty acid trial. Supplementation with vitamin B-12 and n-3 fatty acids corrects hyperhomocysteinemia and reduces platelet reactivity to agonists in vegetarians. Whether this supplementation improves the already reduced cardiovascular morbidity and mortality associated with vegetarian diet has yet tobe demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Documento generato il 05/12/20 alle ore 23:37:04