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Titolo:
Triproline analogues of Pro-Leu-Gly-NH2 with Pro/Leu and Pro/Phe chimeric amino acids in position 2
Autore:
Evans, MC; Johnson, RL;
Indirizzi:
Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 d Chem, Minneapolis, MN 55455 USA
Titolo Testata:
TETRAHEDRON
fascicolo: 50, volume: 56, anno: 2000,
pagine: 9801 - 9808
SICI:
0040-4020(200012)56:50<9801:TAOPWP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-LEUCYL-GLYCINAMIDE; RECEPTOR-MODULATING ACTIVITY; DOPAMINE-D2 RECEPTOR; ASYMMETRIC-SYNTHESIS; PLG; AFFINITY; PEPTIDOMIMETICS; DERIVATIVES; DESIGN; JOM-13;
Keywords:
chimeric amino acids; triproline analogue; proline-leucine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, RL Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 eapolis, MN 55455 USA
Citazione:
M.C. Evans e R.L. Johnson, "Triproline analogues of Pro-Leu-Gly-NH2 with Pro/Leu and Pro/Phe chimeric amino acids in position 2", TETRAHEDRON, 56(50), 2000, pp. 9801-9808

Abstract

Synthesis of the cis- and trans-isomers of the proline-leucine (3-i-Pr-Pro) and proline-phenylalanine (S-Ph-Pro) chimeric amino acids was accomplished by intramolecular reductive-cycloalkylation of the appropriate azido-olefin. These chimeric amino acids were incorporated into the triprolyl analogues of Pro-Leu-Gly-NH2: Pro-cia 3-i-Pr-Pro-Pro-NH2 (3), Pro-trans-3-i-Pr-Pro-Pro-NH2 (4), Pro-cis-3-Ph-Pro-Pro-NH2 (5), Pro-trans-3-Ph-Pro-Pro-NH2 (6). (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:35:39