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Titolo:
Dynamic cerebral autoregulation is unaffected by aging
Autore:
Carey, BJ; Eames, PJ; Blake, MJ; Panerai, RB; Potter, JF;
Indirizzi:
Univ Leicester, Glenfield Hosp, Div Med Elderly, Leicester LE3 9QP, Leics,England Univ Leicester Leicester Leics England LE3 9QP ter LE3 9QP, Leics,England Univ Leicester, Leicester Royal Infirm, Div Med Phys, Leicester, Leics, England Univ Leicester Leicester Leics England d Phys, Leicester, Leics, England
Titolo Testata:
STROKE
fascicolo: 12, volume: 31, anno: 2000,
pagine: 2895 - 2900
SICI:
0039-2499(200012)31:12<2895:DCAIUB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; HYPEREMIC RESPONSE TEST; HEAD-INJURED PATIENTS; DOPPLER ULTRASOUND; CAROTID-ARTERY; SPONTANEOUS FLUCTUATIONS; VALSALVA MANEUVER; FLOW; HUMANS; AGE;
Keywords:
aging; autoregulation; cerebral circulation; ultrasonography, Doppler, transcranial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Carey, BJ Univ Leicester, Glenfield Hosp, Div Med Elderly, Groby Rd, Leicester LE3 9QP, Leics, England Univ Leicester Groby Rd Leicester Leics England LE3 9QP England
Citazione:
B.J. Carey et al., "Dynamic cerebral autoregulation is unaffected by aging", STROKE, 31(12), 2000, pp. 2895-2900

Abstract

Background and Purpose-Normal aging is associated with marked changes in the cardiovascular and cerebrovascular systems. Although cerebral autoregulation (CA) is impaired in certain disease states, the effect of age per se on dynamic CA in humans is unknown and the focus of this study. Methods-Twenty-seven young subjects (less than or equal to 40 years) and 27 older subjects (greater than or equal to 55 years), matched for sex and systolic blood pressure (BP), underwent measurement of cerebral blood flow velocity by transcranial Doppler ultrasound and noninvasive beat-to-beat arterial BP measurement during induced and spontaneous dynamic BP stimuli. A standard dynamic autoregulatory index (ARI) was derived for each spontaneousand induced dynamic BP stimulus to include the step response, as well as cardiac baroreceptor sensitivity (BRS), for the 2 groups. Results-The mean age of the young group was 29+/-5 years, and that of the older group was 68+/-5 years. Cardiac BRS was reduced in the older group (8.6+/-4.5 versus 16.9+/-8.8 ms/mm Hg; P<0.0001). However, no age-related differences were demonstrated in step response plots or in ART values for any presser or depressor dynamic BP stimulus (P=0.62), with mean ARI values forall stimuli combined being 4.9+/-1.8 for the young group and 5.0+/-2.3 forthe older group. Conclusions-Although increasing age is associated with a decrease in cardiac BRS, dynamic CA, as assessed by step response analysis as well as cerebral blood flow responses to transient and induced BP stimuli, is unaffected by aging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:11:30