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Titolo:
SENSITIVE ASSAY FOR PIMOZIDE IN HUMAN PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION - APPLICATION TO PHARMACOKINETIC STUDIES
Autore:
KERBUSCH T; DESTA Z; SOUKHOVA NV; THACKER D; FLOCKHART DA;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,DIV CLIN PHARMACOL,3900 RESERVOIR RD WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,DIV CLIN PHARMACOL WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT MED WASHINGTON DC 20007
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 1, volume: 694, anno: 1997,
pagine: 163 - 168
SICI:
0378-4347(1997)694:1<163:SAFPIH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Keywords:
PIMOZIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
T. Kerbusch et al., "SENSITIVE ASSAY FOR PIMOZIDE IN HUMAN PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION - APPLICATION TO PHARMACOKINETIC STUDIES", Journal of chromatography B. Biomedical sciences and applications, 694(1), 1997, pp. 163-168

Abstract

A method is described for the measurement of pimozide in human plasmausing HPLC with fluorescence detection. The method is specific and sensitive in the range of concentrations seen in human plasma after conventional dosing (1-15 ng/ml) with a limit of quantification of 1 ng/ml. The calibration curves are linear for concentrations between 1 and 50 ng/ml. Within-day and inter-day coefficients of variation are less than 7.4% and 15.5%, respectively, at three concentrations of pimozide (2, 10 and 20 ng/ml). Intra-day and inter-day bias an less than 18.5% and 12.5%, respectively. A pharmacokinetic study conducted in a healthy volunteer administered 6 mg of pimozide orally demonstrates the utility of this method.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 05:40:12