Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinical management of premalignant lesions of the prostate
Autore:
Haggman, MJ; Adolfsson, J; Khoury, S; Montie, JE; Norlen, BJ;
Indirizzi:
Univ Uppsala Hosp, Dept Urol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 t Urol, S-75185 Uppsala, Sweden Huddinge Univ Hosp, Dept Urol, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden Hosp, Dept Urol, Stockholm, Sweden Hop Pitie, Urol Clin, F-75651 Paris, France Hop Pitie Paris France F-75651 p Pitie, Urol Clin, F-75651 Paris, France Univ Michigan, Med Ctr, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USAUniv Michigan, Med Ctr, Ann Arbor, MI USA
Titolo Testata:
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
, volume: 34, anno: 2000, supplemento:, 205
pagine: 44 - 49
SICI:
0036-5599(2000)34:<44:CMOPLO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ADENOMATOUS HYPERPLASIA; INTRAEPITHELIAL NEOPLASIA; NEEDLE-BIOPSY; SEVERE DYSPLASIA; CORE BIOPSIES; DNA-PLOIDY; CANCER; CARCINOMA; ANTIGEN; GRADE;
Keywords:
clinical management guidelines; premalignant lesions; prostate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Haggman, MJ Univ Uppsala Hosp, Dept Urol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 185 Uppsala, Sweden
Citazione:
M.J. Haggman et al., "Clinical management of premalignant lesions of the prostate", SC J UROL N, 34, 2000, pp. 44-49

Abstract

The presence of high-grade prostatic intraepithelial neoplasia (PIN) in a prostate biopsy is a considerable risk factor for the presence of prostate cancer, with up to 73% of patients having cancer on rebiopsy. The risk is related to the clinical setting (screening vs urological practice) and patient factors such as prostatic serum antigen (PSA) and findings on digital rectal examination (DRE). Thus, high-grade PIN has serious clinical implications. The aim of this paper is to propose practical guidelines for the clinical management of PIN. Based on current knowledge we recommend that:Only patients considered for curative treatment of prostate cancer be further investigated for a PIN biopsy finding; A palpable nodule or tumor-suspicious transrectal ultrasonography (TRUS) finding, in conjunction with a finding of high grade PIN on prostate biopsy, should prompt rebiopsy;An elevated PSA level or an elevated PSA density should also warrant repeat biopsy, as the most likely cause of PSA elevation is concomitant prostatecancer;The presence of high-grade PIN on biopsy without concomitant prostate cancer in patients suitable for curative treatment, notwithstanding normal DRE,TRUS or PSA, should prompt repeat biopsies, as the association with prostate cancer is significant;The presence of PIN alone on biopsy does not warrant treatment, as a substantial number of rebiopsies yield only PIN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 14:11:15