Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A possible role of the oxidant tissue injury in the development of hypoxicpulmonary hypertension
Autore:
Herget, J; Wilhelm, J; Novotna, J; Eckhardt, A; Vytasek, R; Mrazkova, L; Ostadal, M;
Indirizzi:
Charles Univ, Fac Med 2, Dept Physiol, Prague 15006 5, Czech Republic Charles Univ Prague Czech Republic 15006 5 rague 15006 5, Czech Republic Charles Univ, Fac Med 2, Dept Med Chem & Biochem, Prague 15006 5, Czech Republic Charles Univ Prague Czech Republic 15006 5 rague 15006 5, Czech Republic
Titolo Testata:
PHYSIOLOGICAL RESEARCH
fascicolo: 5, volume: 49, anno: 2000,
pagine: 493 - 501
SICI:
0862-8408(2000)49:5<493:APROTO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; FREE-RADICAL DAMAGE; HYDROGEN-PEROXIDE; ARTERIAL RELAXATION; LIPID-PEROXIDATION; OXYGEN METABOLITES; COLLAGEN-I; LUNG; RATS; VASOCONSTRICTION;
Keywords:
pulmonary hypertension; chronic hypoxia; pulmonary vasculature; structural remodeling; oxygen free radicals; nitrotyrosine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Herget, J Charles Univ, Fac Med 2, Dept Physiol, Plzenska 221, Prague 15006 5, CzechRepublic Charles Univ Plzenska 221 Prague Czech Republic 15006 5epublic
Citazione:
J. Herget et al., "A possible role of the oxidant tissue injury in the development of hypoxicpulmonary hypertension", PHYSL RES, 49(5), 2000, pp. 493-501

Abstract

Chronic sojourn in hypoxic environment results in the structural remodeling of peripheral pulmonary arteries and pulmonary hypertension. We hypothesize that the pathogenesis of changes in pulmonary vascular structure is related to the increase of radical production induced by lung tissue hypoxia. Hypoxia primes alveolar macrophages to produce more hydrogen peroxide. Furthermore, the increased release of oxygen radicals by other hypoxic lung cells cannot be excluded. Several recent reports demonstrate the oxidant damageof lungs exposed to chronic hypoxia. The production of nitric oxide is high in animals with hypoxic pulmonary hypertension and the serum concentration of nitrotyrosine (radical product of nitric oxide and superoxide interaction) is also increased in chronically hypoxic rats. Antioxidants were shownto be effective in the prevention of hypoxia induced pulmonary hypertension. We suppose that the mechanism by which the radicals stimulate of the vascular remodeling is due to their effect on the metabolism of vascular wall matrix proteins. Non-enzymatic protein alterations and/or activation of collagenolytic matrix metalloproteinases may also participate. The presence oflow-molecular weight cleavage products of matrix proteins stimulates the mesenchymal proliferation in the wall of distal pulmonary arteries. Thickened and less compliant peripheral pulmonary vasculature is then more resistant to the blood flow and the hypoxic pulmonary hypertension is developed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:29:40