Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACUTE CONTRACTILE EFFECTS OF EPIDERMAL GROWTH-FACTOR ON BLADDER SMOOTH MUSCLES - AN IN-VIVO AND IN-VITRO STUDY IN RATS
Autore:
VINTERJENSEN L; KIRIK D; ARNER A; NEXO E; UVELIUS B;
Indirizzi:
AARHUS UNIV HOSP,DEPT CLIN BIOCHEM,NORREBROGADE 44 DK-8000 AARHUS C DENMARK UNIV AARHUS,INST EXPT CLIN RES AARHUS DENMARK LUND UNIV,DEPT PHYSIOL & NEUROSCI LUND SWEDEN LUND UNIV,DEPT UROL LUND SWEDEN
Titolo Testata:
Scandinavian journal of urology and nephrology
fascicolo: 3, volume: 31, anno: 1997,
pagine: 231 - 235
SICI:
0036-5599(1997)31:3<231:ACEOEG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Keywords:
BLADDER; MUSCLE CONTRACTION; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
L. Vinterjensen et al., "ACUTE CONTRACTILE EFFECTS OF EPIDERMAL GROWTH-FACTOR ON BLADDER SMOOTH MUSCLES - AN IN-VIVO AND IN-VITRO STUDY IN RATS", Scandinavian journal of urology and nephrology, 31(3), 1997, pp. 231-235

Abstract

Chronic treatment with epidermal growth factor (EGF) stimulates growth of all wall layers of the urinary tract in pigs and rats. Herein, weinvestigated the acute effects of EGF on detrusor smooth muscle activity. For in vivo examination, awake rats received EGF (75 mu g/kg) intravenously and detrusor smooth muscle activity was monitored cystometrically. The EGF bolus caused no alteration in diuresis but a doubling of the micturition frequency, a 25% increase in micturition pressures,and increased irregular baseline contractile activity. For in vitro examination detrusor smooth muscle strips were exposed to EGF (1 mu g/ml). EGF caused contraction and increase in the spontaneous activity. In conclusion, EGF increases rat detrusor smooth muscle contractile activity in vivo and in vitro. The finding suggests that a direct effect of EGF on bladder smooth muscles is part of the genesis to the growth of the detrusor smooth muscle observed after chronic EGF treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:06:44