Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interaction between haemochromatosis and transferrin receptor genes in hepatocellular carcinoma
Autore:
Beckman, LE; Hagerstrand, I; Stenling, R; Van Landeghem, GF; Beckman, L;
Indirizzi:
Umea Univ, Dept Med Biosci, SE-90185 Umea, Sweden Umea Univ Umea Sweden SE-90185 v, Dept Med Biosci, SE-90185 Umea, Sweden Umea Univ, Dept Diagnost Radiol Oncol & Radiat Phys, SE-90185 Umea, SwedenUmea Univ Umea Sweden SE-90185 ncol & Radiat Phys, SE-90185 Umea, Sweden Umea Univ, Dept Med Biosci, SE-90185 Umea, Sweden Umea Univ Umea Sweden SE-90185 v, Dept Med Biosci, SE-90185 Umea, Sweden
Titolo Testata:
ONCOLOGY
fascicolo: 4, volume: 59, anno: 2000,
pagine: 317 - 322
SICI:
0030-2414(2000)59:4<317:IBHATR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORPHYRIA-CUTANEA-TARDA; HEREDITARY HEMOCHROMATOSIS; LIVER-DISEASES; HEPATITIS-C; MUTATION; IRON; PREVALENCE; HFE; POLYMORPHISMS; POPULATION;
Keywords:
hepatocellular carcinoma; haemochromatosis gene; transferrin receptor gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Beckman, L Umea Univ, Dept Med Biosci, SE-90185 Umea, Sweden Umea Univ Umea Sweden SE-90185 Biosci, SE-90185 Umea, Sweden
Citazione:
L.E. Beckman et al., "Interaction between haemochromatosis and transferrin receptor genes in hepatocellular carcinoma", ONCOL-BASEL, 59(4), 2000, pp. 317-322

Abstract

In hepatocellular carcinoma (HCC) iron has been implicated as a risk factor prima ri ly in patients with hereditary haemochromatosis (HH) and cirrhosis. The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron. In previous studies we found an interaction between HFE and TFR genotypes in multiple myeloma and breast and colorectal carcinomas. In the present investigation we have studied HFE and TFR genotypes in 54 Swedish patients with HCC, using DNA from archival samples of paraffin wax blocks. The same HFE-TFR interaction as in the previously studied neoplastic disorders was found. Individuals carrying the HFE282Tyr allele (homo- and heterozygotes) in combination with homozygosity for the TFR Ser allele showed an increased risk for HCC (OR = 3.5; 95% confidence interval, Cl = 1.3-9.3), which was further increased in HFE Tyr homozygotes and compound (Tyr/Asp) heterozygotes in combination with TFR 142Ser homozygosity (OR = 17.2; 95% Cl = 1.8-168.9). The presence of liver cirrhosis could only be assessed in part of the patient material. In patients with verified liver cirrhosis the risk figures were substantially increased: for HFE 282 Tyr carriersin combination with TFR 142Ser/Ser OR = 7.2; 95% Cl = 2.0-25.5 and for HFE282Tyr homozygotes and compound heterozygotes in combination with TFR 142Ser homozygosity, OR = 62.8; 95% CI = 6.1-642.5. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 10:55:31