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Titolo:
Proliferation index of nonfunctioning pituitary adenomas: Correlations with clinical characteristics and long-term follow-up results
Autore:
Losa, M; Franzin, A; Mangili, F; Terreni, MR; Barzaghi, R; Veglia, F; Mortini, P; Giovanelli, M;
Indirizzi:
Univ Milan, Dept Neurosurg, IRCCS San Raffaele, Pituitary Unit, I-20132 Milan, Italy Univ Milan Milan Italy I-20132 ele, Pituitary Unit, I-20132 Milan, Italy Univ Milan, Dept Pathol, IRCCS San Raffaele, I-20132 Milan, Italy Univ Milan Milan Italy I-20132 IRCCS San Raffaele, I-20132 Milan, Italy Univ Milan, Biostat Unit, IRCCS San Raffaele, I-20132 Milan, Italy Univ Milan Milan Italy I-20132 IRCCS San Raffaele, I-20132 Milan, Italy
Titolo Testata:
NEUROSURGERY
fascicolo: 6, volume: 47, anno: 2000,
pagine: 1313 - 1318
SICI:
0148-396X(200012)47:6<1313:PIONPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY KI-67; GROWTH-RATE; RECURRENCE; RADIOTHERAPY; CRITERIA; SURGERY; MIB-1; SINUS;
Keywords:
Ki-67; nonfunctioning adenoma; pituitary neoplasm; pituitary surgery; proliferation markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Losa, M Univ Milan, Dept Neurosurg, IRCCS San Raffaele, Pituitary Unit, Via Olgettina 60, I-20132 Milan, Italy Univ Milan Via Olgettina 60 Milan Italy I-20132 0132 Milan, Italy
Citazione:
M. Losa et al., "Proliferation index of nonfunctioning pituitary adenomas: Correlations with clinical characteristics and long-term follow-up results", NEUROSURGER, 47(6), 2000, pp. 1313-1318

Abstract

OBJECTIVE: The recurrence of nonfunctioning pituitary adenomas (NFPAs) after surgical removal is common. The aim of our study was to investigate and correlate the growth fraction of NFPAs with clinical characteristics and long-term follow-up results. METHODS: Tumor specimens were obtained from 101 consecutive patients with NFPAs (48 female patients and 53 male patients; mean age, 52.0 +/- 1.5 yr). Specimens were immediately fixed in 10% buffered formalin and then embedded in paraffin. The Ki-67 antigen was assessed by immunocytochemical analysis using the monoclonal antibody MIB-1. The Ki-67 antigen labeling index (LI) was determined by counting a total of at least 1000 neoplastic nuclei. RESULTS: The mean Ki-67 LI for the 101 patients was 2.4 +/- 0.3% (range, 0-23.0%). Only age at surgery was inversely correlated with the Ki-67 LI; sex, maximal tumor diameter, and invasiveness into the cavernous sinuses did not significantly affect the Ki-67 LI. The mean follow-up period was 39.7 +/- 2.1 months. During follow-up monitoring, 23 patients experienced tumor recurrence, after a mean period of 28.6 +/- 4.8 months. Invasiveness of the tumor on preoperative magnetic resonance imaging scans was the strongest predictor of late tumor recurrence, followed by previous pituitary surgery, younger age, and lack of postoperative radiotherapy. The Ki-67 LI had no independent prognostic value. CONCLUSION: Our study suggests that the clinical characteristics of patients with NFPAs, except for age at surgery, are not correlated with the Ki-67LI. Moreover, the Ki-67 LI does not seem to provide independent information to identify patients at high risk for tumor recurrence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:51:34