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Titolo:
Hormonal regulation of hippocampal spine synapse density involves subcortical mediation
Autore:
Leranth, C; Shanabrough, M; Horvath, TL;
Indirizzi:
Yale Univ, Sch Med, Dept Obstet & Gynecol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 bstet & Gynecol, New Haven, CT 06520 USA Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Neurobiol Sect, New Haven, CT 06520 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 101, anno: 2000,
pagine: 349 - 356
SICI:
0306-4522(2000)101:2<349:HROHSS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR-ALPHA; DISCRETE BRAIN NUCLEI; RAT PREOPTIC AREA; FEMALE RATS; ESTRADIOL INCREASES; CONTAINING NEURONS; MESSENGER-RNA; DIAGONAL BAND; INHIBITORY INTERNEURONS; CONTAINING AFFERENTS;
Keywords:
estrogen; synaptic plasticity; CA1 area; septal complex; supramammillary area; median raphe;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Leranth, C Yale Univ, Sch Med, Dept Obstet & Gynecol, 333 Cedar St,FMB 328, New Haven, CT 06520 USA Yale Univ 333 Cedar St,FMB 328 New Haven CT USA 06520 06520 USA
Citazione:
C. Leranth et al., "Hormonal regulation of hippocampal spine synapse density involves subcortical mediation", NEUROSCIENC, 101(2), 2000, pp. 349-356

Abstract

It is well established that estrogen has positive effects on the density of pyramidal cell spines in the hippocampal CA1 subfield. This study explored whether afferent connections of the hippocampus that come from estrogen-sensitive subcortical structures, including the septal complex, median rapheand supramammillary area, play a role in this estrogen-induced hippocampalsynaptic plasticity. These particular subcortical structures have major influences on hippocampal activity, including theta rhythm and long-term potentiation. The latter also promotes the formation of new synapses. All of the rats were ovariectomized; the fimbria/fornix, which contains the majorityof subcortical efferents to the hippocampus, was transected unilaterally in each, and half of the animals received estrogen replacement. Using unbiased electron microscopic stereological methods, the CA1 pyramidal cell spinesynapse density was calculated. In the estrogen-treated rats, contralateral to the fimbria/fornix transection, the spine density of CA1 pyramidal cells increased dramatically, compared to the spine density values of both theipsilateral and contralateral hippocampi of non-estrogen-treated animals and to that of the ipsilateral hippocampus of the estrogen replaced rats. These observations indicate that fimbria/fornix transection itself does not considerably influence CA1 area pyramidal cell spine density and, most importantly, that the estrogenic effect on hippocampal morphology, in addition to directly affecting the hippocampus, involves subcortical mediation. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:20:34