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Titolo:
Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers
Autore:
Domino, EF; Minoshima, S; Guthrie, SK; Ohl, L; Ni, L; Koeppe, RA; Cross, DJ; Zubieta, JK;
Indirizzi:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Internal Med Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ed Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Coll Pharm, Ann Arbor, MI 48109 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 101, anno: 2000,
pagine: 277 - 282
SICI:
0306-4522(2000)101:2<277:EONORC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; FUNCTIONAL BRAIN IMAGES; STRIATE CORTEX; NASAL SPRAY; BLOOD-FLOW; RAT; SMOKING; LOCALIZATION; PLASMA; STANDARDIZATION;
Keywords:
regional cerebral metabolism; brain glucose; nicotine; tobacco smokers; tobacco abstinence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Domino, EF Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 , Ann Arbor, MI 48109 USA
Citazione:
E.F. Domino et al., "Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers", NEUROSCIENC, 101(2), 2000, pp. 277-282

Abstract

Eleven healthy tobacco smoking adult male volunteers of mixed race were tobacco abstinent overnight for this study. In each subject, positron emission tomographic images of regional cerebral metabolism of glucose with [F-18]fluorodeoxyglucose were obtained in two conditions in the morning on different days: about 3 min after approximately 1-2 mg of nasal nicotine spray and after an equivalent volume of an active placebo spray of oleoresin of pepper in a random counterbalanced design. A Siemens/CTI 931/08-12 scanner with the capability of 15 horizontal brain slices was used. The images were further converted into a standard uniform brain format in which the mean dataof all 11 subjects were obtained. Images were analysed in stereotactic coordinates using pixel-wise a statistics and a smoothed Gaussian model. Peak plasma nicotine levels varied three-fold and the areas under the curve(0-30min) varied seven-fold among the individual subjects. Nicotine caused a small overall reduction in global cerebral metabolism of glucose but, when the data were normalized, several brain regions showed relative increases in activity. Cerebral structures specifically activated by nicotine (nicotine minus pepper, Z score >4.0) included: left inferior frontal gyrus, left posterior cingulate gyrus and right thalamus. The visual cortex, including theright and left cuneus and left lateral occipito-temporal gyrus fusiformis,also showed an increase in regional cerebral metabolism of glucose with Z scores >3.6. Structures with a decrease in regional cerebral metabolism of glucose (pepper minus nicotine) were the left insula and right inferior occipital gyrus, with Z scores >3.5. Especially important is the fact that the thalamus is activated by nicotine. This is consistent with the high density of nicotinic cholinoceptors in that brain region. However, not all brain regions affected by nicotine are known to have many nicotinic cholinoceptors. The results are discussed in relation to the cognitive effects of nicotine. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:21:26