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Titolo:
Congenital helpless rats as a genetic model for cortex metabolism in depression
Autore:
Shumake, J; Poremba, A; Edwards, E; Gonzalez-Lima, F;
Indirizzi:
Univ Texas, Dept Psychol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Texas, Dept Psychol, Austin, TX 78712 USA Univ Texas, Inst Neurosci, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Texas, Inst Neurosci, Austin, TX 78712 USA NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA Univ MarylandBaltimore MD USA 21201 rmaceut Sci, Baltimore, MD 21201 USA
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 11, anno: 2000,
pagine: 3793 - 3798
SICI:
0959-4965(20001127)11:17<3793:CHRAAG>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; PREFRONTAL CORTEX; UNIPOLAR DEPRESSION; GLUCOSE-METABOLISM; MAJOR DEPRESSION; ABNORMALITIES; MELANCHOLIA; PROJECTIONS; DISORDERS;
Keywords:
brain mapping; cingulate; congenital learned helplessness; cytochrome oxidase; depression; genetic model; metabolism; prefrontal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez-Lima, F Univ Texas, Dept Psychol, Mezes Hall 330, Austin, TX 78712 USA Univ Texas Mezes Hall 330 Austin TX USA 78712 X 78712 USA
Citazione:
J. Shumake et al., "Congenital helpless rats as a genetic model for cortex metabolism in depression", NEUROREPORT, 11(17), 2000, pp. 3793-3798

Abstract

The validity of congenital helplessness as a genetic rat model for human depression was investigated in cortical regions of the rat brain thought to be analogous to those showing abnormalities in human neuroimaging studies. Cortex metabolism was analyzed using quantitative cytochrome oxidase histochemistry. Congenital helpless rats showed changes in frontal and cingulate regions comparable to those that have demonstrated metabolic differences inhuman depression. Significant metabolic decreases were found in dorsal frontal, medial orbital, and anterior cingulate, whereas a significant increase was found in infraradiata (subgenual) cingulate. The direction of these changes were the same as those seen in human studies. These findings supportthe validity of congenital helplessness as a model for human depression. NeuroReport 11:3793-3798 (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 04/07/20 alle ore 21:29:06