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Titolo:
A readily releasable pool of single inhibitory boutons in culture
Autore:
Kirischuk, S; Grantyn, R;
Indirizzi:
Humboldt Univ, Med Sch Charite, Johannes Muller Inst Physiol, D-10117 Berlin, Germany Humboldt Univ Berlin Germany D-10117 st Physiol, D-10117 Berlin, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 11, anno: 2000,
pagine: 3709 - 3713
SICI:
0959-4965(20001127)11:17<3709:ARRPOS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-DEPENDENCE; VESICLE POOLS; SYNAPSES; DEPRESSION; EXOCYTOSIS; RECEPTORS; NEURONS; QUANTA; SIZE;
Keywords:
GABAergic synaptic transmission; IPSC; presynaptic vesicle; readily releasable pool; RH414;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kirischuk, S Humboldt Univ, Med Sch Charite, Johannes Muller Inst Physiol,Tucholskystr2, D-10117 Berlin, Germany Humboldt Univ Tucholskystr 2 Berlin Germany D-10117 Germany
Citazione:
S. Kirischuk e R. Grantyn, "A readily releasable pool of single inhibitory boutons in culture", NEUROREPORT, 11(17), 2000, pp. 3709-3713

Abstract

The number of presynaptic vesicles that are immediately available for release, the readily releasable pool (RRP), is a strong determinant of synapticstrength and plasticity. The properties of the RRP in individual GABAergicsynapses were examined in superior colliculus cultures. The RRP was depleted by high frequency trains and cumulative evoked IPSC amplitudes (CA) werecalculated. The amplitude of monoquantal responses (q) was determined on the basis of mlPSC histograms. On; average, the RRP, defined as CA/q,comprised about [0 vesicles. About 60% of the RRP could be released by a single stimulus. After depletion, the RRP was replenished with a time constant of about 14s. These data provide information for further studies on the capacityof individual inhibitory synapses to modulate sensory information transfer. NeuroReport 11:3709-3713 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:26:36