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Titolo:
Nociceptin/orphanin FQ inhibits ischaemia-induced glutamate efflux from rat cerebrocortical slices
Autore:
Nelson, RM; Calo, G; Guerrini, R; Hainsworth, AH; Green, AR; Lambert, DG;
Indirizzi:
Leicester Royal Infirm, Dept Anaesthesia, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW WW, Leics, England AstraZeneca R&D, Loughborough, Leics, England AstraZeneca R&D Loughborough Leics England Loughborough, Leics, England Univ Ferrara, Dept Pharmacol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 ept Pharmacol, I-44100 Ferrara, Italy Univ Ferrara, Dept Pharmaceut Sci, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 harmaceut Sci, I-44100 Ferrara, Italy De Montfort Univ, Sch Pharm & Pharmaceut Sci, Leicester LE1 9BH, Leics, England De Montfort Univ Leicester Leics England LE1 9BH LE1 9BH, Leics, England
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 11, anno: 2000,
pagine: 3689 - 3692
SICI:
0959-4965(20001127)11:17<3689:NFIIGE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC BRAIN INJURY; ORPHANIN-FQ; RECEPTOR; NEURONS; CHLORMETHIAZOLE; RELEASE; STROKE;
Keywords:
glutamate efflux; ischaemia; neuroprotection; nociceptin/orphanin FQ; stroke;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nelson, RM Leicester Royal Infirm, Dept Anaesthesia, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW England
Citazione:
R.M. Nelson et al., "Nociceptin/orphanin FQ inhibits ischaemia-induced glutamate efflux from rat cerebrocortical slices", NEUROREPORT, 11(17), 2000, pp. 3689-3692

Abstract

Nociceptin/orphanin PQ (NC), the endogenous ligand for the G-protein coupled nociceptin receptor (NCR), has a modulatory role in various physiological processes including neurotransmitter release. We have examined the effects of NC, the analogues NC(1-13)NH2 and [F/G]NC(1-13)NH2 and the competitiveantagonist [Nphe(1)]NC(1-13)NH2 (Nphe(1)) on glutamate efflux during an acute simulated ischaemic challenge in rat cerebrocortical slices. The increase in glutamate efflux seen with ischaemia was inhibited by NC (EC50 250 nM). At micromolar concentrations, the analogues were found to have a similareffect on glutamate efflux compared to NC. In all cases, inhibition of glutamate efflux was abolished by Nphe(1) (30 muM). These results suggest a neuroprotective action for NC. NeuroReport 11:3689-3692 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:28:14