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Titolo:
Augmented accumbal serotonin levels decrease the preference for a morphineassociated environment during withdrawal
Autore:
Harris, GC; Aston-Jones, G;
Indirizzi:
Univ Penn, VAMC, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA19104 enn, VAMC, Philadelphia, PA 19104 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 24, anno: 2001,
pagine: 75 - 85
SICI:
0893-133X(200101)24:1<75:AASLDT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; EXTRACELLULAR DOPAMINE LEVELS; KAINIC ACID LESIONS; NUCLEUS-ACCUMBENS; CHRONIC FLUOXETINE; OPIATE WITHDRAWAL; INDUCED INCREASES; DRUG-DEPENDENCE; ABUSE PATIENTS; HEROIN REWARD;
Keywords:
serotonin; fluoxetine; 5-HTP; morphine; withdrawal; place conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Aston-Jones, G Univ Penn, VAMC, 151 Rm A520,Univ & Woodland Ave, Philadelphia, PA 19104 USA Univ Penn 151 Rm A520,Univ & Woodland Ave Philadelphia PAUSA 19104
Citazione:
G.C. Harris e G. Aston-Jones, "Augmented accumbal serotonin levels decrease the preference for a morphineassociated environment during withdrawal", NEUROPSYCH, 24(1), 2001, pp. 75-85

Abstract

Recent studies have found that acute morphine administration increases serotonin (5-HT) transmission within the nucleus accumbens and other forebrainregions. In contrast, 5-HT transmission is depressed during withdrawal from chronic morphine. We show that pharmacological agents that increase brain5-HT levels (fluoxetine or 5-hydoxytryptophan, 5-HTP) abolish the preference of chronically morphine-treated, withdrawn mts for a morphine-associatedenvironment. Similar results were seen when fluoxetine was microinjected into the nucleus accumbens. Conversely, rats given morphine acutely showed an enhanced preference for a morphine-associated environment when pretreatedwith these agents. Fluoxetine also decreased the heightened anxiety found in morphine withdrawn rats. The results of our study indicate that drugs that augment 5-HT levels may reduce the desire for morphine during withdrawal. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:25:58