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Titolo:
The effect of clozapine on caudate nucleus volume in schizophrenic patients previously treated with typical antipsychotics
Autore:
Scheepers, FE; de Wied, CCG; Pol, HEH; van de Flier, W; van der Linden, JA; Kahn, RS;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Psychiat, NL-3508 GA Utrecht, Netherlands UnivUtrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 24, anno: 2001,
pagine: 47 - 54
SICI:
0893-133X(200101)24:1<47:TEOCOC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATMENT-REFRACTORY SCHIZOPHRENICS; POSITRON-EMISSION-TOMOGRAPHY; BASAL GANGLIA; TARDIVE-DYSKINESIA; NEUROLEPTIC TREATMENT; DOPAMINE HYPOTHESIS; PREFRONTAL CORTEX; NEGATIVE SYMPTOMS; BRAIN MORPHOLOGY; ABNORMALITIES;
Keywords:
schizophrenia; caudate nucleus; clozapine; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Scheepers, FE Univ Utrecht, Med Ctr, Dept Psychiat, A00-241,POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht A00-241,POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
F.E. Scheepers et al., "The effect of clozapine on caudate nucleus volume in schizophrenic patients previously treated with typical antipsychotics", NEUROPSYCH, 24(1), 2001, pp. 47-54

Abstract

Typical antipsychotics have been reported to enlarge the caudate nucleus in schizophrenic patients. The atypical antipsychotic, clozapine, is associated with a decrease in caudate size in patients previously treated with typical antipsychotics. The present study investigates whether a change in caudate volume after switching from treatment with typical antipsychotics to treatment with clozapine is related to improvement in symptoms or tardive dyskinesia (TD). Twenty-six schizophrenic patients participated in this open study. Caudate nucleus volume and TD were assessed before discontinuing typical antipsychotics and after 24 weeks of treatment with clozapine. After discontinuing typical antipsychotics, symptoms were assessed in a 3 days drug-free period and subsequently once a month. Treatment with clozapine resulted in a decrease in caudate volume, improvement in symptoms and amelioration of TD. However, no difference in caudate volume changes was found between responders and non-responders to clozapine and no correlations were foundbetween caudate volume changes and reduction of TD. In conclusion, this study replicates earlier findings that colzapine decreases caudate volume in patients previously treated with typical antipsychotics and suggests that this effect is unrelated to treatment response or to amelioration of TD. (C)2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 21/01/20 alle ore 07:06:44