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Titolo:
Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia
Autore:
Maes, M; van West, D; De Vos, N; Westenberg, H; Van Hunsel, F; Hendriks, D; Cosyns, P; Scharpe, S;
Indirizzi:
Univ Maastricht, Dept Psychiat & Neuropsychol, Maastricht, Netherlands Univ Maastricht Maastricht Netherlands psychol, Maastricht, Netherlands Clin Res Ctr Mental Hlth, Antwerp, Belgium Clin Res Ctr Mental Hlth Antwerp Belgium Mental Hlth, Antwerp, Belgium Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA Univ Utrecht, Dept Psychiat, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands t, Dept Psychiat, Utrecht, Netherlands Univ Antwerp, Dept Biochem Med, Wilrijk, Belgium Univ Antwerp Wilrijk Belgium ntwerp, Dept Biochem Med, Wilrijk, Belgium Univ Antwerp Hosp, Dept Psychiat, Edegem, Belgium Univ Antwerp Hosp Edegem Belgium p Hosp, Dept Psychiat, Edegem, Belgium
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 24, anno: 2001,
pagine: 37 - 46
SICI:
0893-133X(200101)24:1<37:LBPCAP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
META-CHLOROPHENYLPIPERAZINE; IMPULSIVE AGGRESSION; VIOLENT OFFENDERS; SCHIZOPHRENIC-PATIENTS; PERSONALITY-DISORDERS; SEROTONERGIC FUNCTION; HEALTHY-VOLUNTEERS; RECEPTOR-BINDING; 5-HT2A RECEPTOR; RHESUS-MONKEYS;
Keywords:
serotonin; pedophilia; meta-chlorophenylpiperazine; paraphilias; violence; aggression; cortisol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Maes, M Univ Hosp Maastricht, Dept Psychiat & Neuropsychol, Postbus 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Postbus 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
M. Maes et al., "Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia", NEUROPSYCH, 24(1), 2001, pp. 37-46

Abstract

There is some evidence that hormonal and serotonergic alterations may playa role in the pathophysiology of paraphilias. The aims of the present study were to examine: 1) baseline plasma cortisol, plasma prolactin, and body temperature; and 2) cortisol, prolactin, body temperature, as well as behavioral responses to metachlorophenylpiperazine (mCPP) and placebo in pedophiles and normal men. Pedophiles showed significantly lower baseline plasma cortisol and prolactin concentrations and a higher body temperature than normal volunteers. The mCPP-induced cortisol responses were significantly greater in pedophiles than in normal volunteers. In normal volunteers, mCPP-induced a hyperthermic response, whereas in pedophiles no such response was observed. mCPP induced different behavioral responses in pedophiles than in normal men. In pedophiles, but not in normal men, mCPP increased the sensations "feeling dizzy," "restless," and "strange" and decreased the sensation "feeling hungry". The results suggest that there are several serotonergic disturbances in pedophiles. It is hypothesized that the results are compatible with a decreased activity of the serotonergic presynaptic neuron and a 5-HT2 postsynaptic receptor hyperresponsivity. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:29:27