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Titolo:
Desensitization of 5-HT1A autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635
Autore:
Hervas, I; Vilaro, MT; Romero, L; Scorza, MC; Mengod, G; Artigas, F;
Indirizzi:
IDIBAPS, CSIC, Inst Invest Biomed Barcelona, Dept Neurochem, Barcelona 08036, Spain IDIBAPS Barcelona Spain 08036 na, Dept Neurochem, Barcelona 08036, Spain Inst Clemente Estable, Montevideo, Uruguay Inst Clemente Estable Montevideo Uruguay e Estable, Montevideo, Uruguay
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 24, anno: 2001,
pagine: 11 - 20
SICI:
0893-133X(200101)24:1<11:DO5ABA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; IN-VIVO MICRODIALYSIS; SEROTONIN REUPTAKE INHIBITORS; DORSAL RAPHE NUCLEUS; INCREASES EXTRACELLULAR SEROTONIN; RAT-BRAIN; MAJOR DEPRESSION; RECEPTOR ANTAGONISTS; DOUBLE-BLIND; FRONTAL-CORTEX;
Keywords:
5-hydroxytryptamine uptake; 5-HT1A receptors; dorsal raphe nucleus; frontal cortex; microdialysis; selective serotonin reuptake inhibitors (SSRI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Artigas, F IDIBAPS, CSIC, Inst Invest Biomed Barcelona, Dept Neurochem, Rossello 161,6th Floor, Barcelona 08036, Spain IDIBAPS Rossello 161,6th FloorBarcelona Spain 08036 36, Spain
Citazione:
I. Hervas et al., "Desensitization of 5-HT1A autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635", NEUROPSYCH, 24(1), 2001, pp. 11-20

Abstract

Using microdialysis, receptor autoradiography and in situ hybridization, we examined the effects of fluoxetine alone or with WAY-100635 on: (a) extracellular 5-HT in frontal cortex; and (b) density and sensitivity of 5-HT1A autoreceptors in rat brain. WAY-100635 (0.3 mg/kg, s.c.) doubled the increase in extracellular 5-HT produced by fluoxetine (3 mg/kg, i.p.) in frontal cortex. Two-week minipump treatments with these daily doses significantly raised extracellular 5-HT to 275 +/- 33% (fluoxetine) and 245 +/- 10% (fluoxetine plus WAY-100635) of controls. Fluoxetine 3 mg/kg day desensitized dorsal raphe 5-HT1A autoreceptors, an effect prevented by the concurrent WAY-100635 administration. However, WAY-100635 (alone or with fluoxetine) did not change 5-HT1A autoreceptor sensitivity. The density of 5-HT1A receptors and its encoding mRNA, was unaffected by these treatments. These results suggest that prolonged blockade of 5-HT1A receptors in vivo prevents the autoreceptor desensitization induced by fluoxetine but does not result in receptor sensitization. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:38:36