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Titolo:
Involvement of potassium channels in amitriptyline and clomipramine analgesia
Autore:
Galeotti, N; Ghelardini, C; Bartolini, A;
Indirizzi:
Univ Florence, Dept Pharmacol, I-50139 Florence, Italy Univ Florence Florence Italy I-50139 Pharmacol, I-50139 Florence, Italy
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 1, volume: 40, anno: 2001,
pagine: 75 - 84
SICI:
0028-3908(2001)40:1<75:IOPCIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE ION CHANNELS; K+ CHANNELS; RECEPTOR SUBTYPES; MAMMALIAN NEURONS; ANTINOCICEPTION; AGONISTS; MICE; MORPHINE; PHARMACOLOGY; MODULATION;
Keywords:
K+ channel; analgesia; clomipramine; amitriptyline; tricyclic antidepressants; minoxidil; pinacidil; gliquidone; apamin; tetraethylammonium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ghelardini, C Univ Florence, Dept Pharmacol, Viale G Pieraccini 6, I-50139Florence, Italy Univ Florence Viale G Pieraccini 6 Florence Italy I-50139y
Citazione:
N. Galeotti et al., "Involvement of potassium channels in amitriptyline and clomipramine analgesia", NEUROPHARM, 40(1), 2001, pp. 75-84

Abstract

The effect of the administration of modulators of different subtypes of Kchannels on antinociception induced by the tricyclic antidepressants amitriptyline and clomipramine was evaluated in the mouse hot plate test. The administration of the voltage-gated K+ channel blocker tetraethylammonium (0.01-0.5 mug per mouse i.c.v.) prevented antinociception induced by both amitriptyline (15 mg kg(-1) s.c.) and clomipramine (25 mg kg(-1) s.c.). The K-ATP, channel blocker gliquidone (0.1-1.0 mug per mouse i.c.v.) prevented antinociception produced by amitriptyline and clomipramine whereas the K-ATP channel openers minoxidil (10 mug per mouse i.c.v.) and pinacidil (25 mug per mouse i.c.v.) potentiated tricyclic antidepressant-induced analgesia. Theadministration of the Ca2+-gated K+ channel blocker apamin (0.1-1.0 ng permouse i.c.v.) completely prevented amitriptyline and clomipramine analgesia. At the highest effective doses, none of the drugs used induced behavioural side effects or impaired motor coordination, as revealed by the rota-rodtest, spontaneous motility or inspection activity, as revealed by the holeboard test. The present results demonstrate that central antinociception induced by amitriptyline and clomipramine involves the opening of different subtypes of K+ channels (voltage-gated, K-ATP and Ca2+-gated) which, therefore, represent a step in the transduction mechanism of tricyclic antidepressant analgesia. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:38:24