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Titolo:
The role of the dorsolateral prefrontal cortex in random number generation: A study with positron emission tomography
Autore:
Jahanshahi, M; Dirnberger, G; Fuller, R; Frith, CD;
Indirizzi:
Natl Hosp Neurol & Neurosurg, Inst Neurol, Dept Clin Neurol, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England Natl Hosp Neurol & Neurosurg, Inst Neurol, Dept Cognit Neurol, London WC1N3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG on WC1N3BG, England
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 12, anno: 2000,
pagine: 713 - 725
SICI:
1053-8119(200012)12:6<713:TROTDP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERBAL WORKING-MEMORY; CEREBRAL ACTIVATION; FRONTAL-LOBE; HUMAN BRAIN; CEREBELLAR; SUPPRESSION; SELECTION; ATTENTION; MOVEMENT; SYSTEMS;
Keywords:
random number generation; dorsolateral prefrontal cortex; executive function; response selection; response suppression; PET; network modulation model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Jahanshahi, M Natl Hosp Neurol & Neurosurg, Inst Neurol, Dept Clin Neurol,Queen Sq, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg Queen Sq London England WC1N 3BG
Citazione:
M. Jahanshahi et al., "The role of the dorsolateral prefrontal cortex in random number generation: A study with positron emission tomography", NEUROIMAGE, 12(6), 2000, pp. 713-725

Abstract

Random number generation (RNG) engages a number of executive processes. Weused positron emission tomography (PET) to measure regional cerebral bloodflow (rCBF) in six volunteers who performed RNG and a control counting (COUNT) task at six rates paced by a tone. This provided a systematic variation of difficulty of RNG. Relative to COUNT, RNG was associated with significant activation of the left dorsolateral prefrontal cortex (DLPFC), the anterior cingulate, the superior parietal cortex bilaterally, the right inferior frontal cortex, and the left and right cerebellar hemispheres. Faster rates of RNG were associated with a significant decrease in regional cerebral blood how (rCBF) in the left and right DLPFC and the right superior parietal cortex. rCBF in the left DLPFC was significantly and negatively associated with count score 1, a measure of habitual counting during RNG. These results are discussed in relation to the network modulation model of RNG; developed on the basis of our previous studies using transcranial magnetic stimulation and dual task paradigms. This suggests that during RNG;, suppressionof habitual counting is achieved through the modulatory (inhibitory) influence of the left DLPFC over a number associative network distributed in thesuperior temporal cortex. At faster rates of RNG the synchronization demands of paced RNG result in the breakdown of this modulatory influence, whichis evident from decreased rCBF in the left DLPFC and increased habitual counting at faster rates. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:15:47