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Titolo:
Expression of the Fc receptor in the mammary gland during lactation in themarsupial Trichosurus vulpecula (brushtail possum)
Autore:
Adamski, FM; King, AT; Demmer, J;
Indirizzi:
AgRes Ruakura, Reprod Technol Grp, Hamilton, New Zealand AgRes Ruakura Hamilton New Zealand d Technol Grp, Hamilton, New Zealand
Titolo Testata:
MOLECULAR IMMUNOLOGY
fascicolo: 8, volume: 37, anno: 2000,
pagine: 435 - 444
SICI:
0161-5890(200006)37:8<435:EOTFRI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL FC RECEPTOR; POUCH-YOUNG MARSUPIALS; CRYSTAL-STRUCTURE; MACROPUS-EUGENII; HUMAN PLACENTA; IGG; IMMUNOGLOBULIN; MICE; TRANSPORT; FETAL;
Keywords:
reproductive immunology; Fc receptors; antibodies; transporters; molecular biology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Demmer, J AgRes Ruakura, Reprod Technol Grp, Private Bag 3123, Hamilton, New Zealand AgRes Ruakura Private Bag 3123 Hamilton New Zealand ew Zealand
Citazione:
F.M. Adamski et al., "Expression of the Fc receptor in the mammary gland during lactation in themarsupial Trichosurus vulpecula (brushtail possum)", MOL IMMUNOL, 37(8), 2000, pp. 435-444

Abstract

One of several functions described for the Fc receptor is regulation of IgG isotype transport into milk. The first marsupial homologues of the Fc receptor heavy and light chains, FcRn and beta -2 microglobulin, from the brushtail possum have been cloned and characterised. The level of FcRn mRNA in the possum mammary gland was highest at the start of lactation, and decreased slowly thereafter. Expression of FcRn mRNA did not increase during the switch phase when the concentration of IgG in milk is highest. In contrast, the level of beta -2 microglobulin mRNA in the mammary gland increased during the switch phase when milk IgG concentration also increases. This correlation between beta -2 microglobulin mRNA expression in the mammary gland with the time of active IgG-transfer into milk was also observed in the bovine and murine mammary gland. This suggests that expression of the Fc receptor in the mammary gland is controlled by the expression of beta -2 microglobulin and that its expression is upregulated during the period of highest IgG-transfer into milk. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 05:19:55