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Titolo:
Toxic liver damage through HMG-CoA-reductase inhibitors
Autore:
Heuer, T; Gerards, H; Pauw, M; Gabbert, HE; Reis, HE;
Indirizzi:
Krankenhaus Maria Hilf, Med Klin 1, Monchengladbach, Germany Krankenhaus Maria Hilf Monchengladbach Germany Monchengladbach, Germany
Titolo Testata:
MEDIZINISCHE KLINIK
fascicolo: 11, volume: 95, anno: 2000,
pagine: 642 - 644
SICI:
0723-5003(20001115)95:11<642:TLDTHI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
GER
Soggetto:
SIMVASTATIN; SAFETY; HYPERCHOLESTEROLEMIA; DISEASE;
Keywords:
toxic hepatitis; HMG-CoA-reductase inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Heuer, T Kliniken Maria Hilf, Med Klin 1, Viersener Str 450, D-41063 Monchengladbach, Germany Kliniken Maria Hilf Viersener Str 450 Monchengladbach Germany D-41063
Citazione:
T. Heuer et al., "Toxic liver damage through HMG-CoA-reductase inhibitors", MED KLIN, 95(11), 2000, pp. 642-644

Abstract

Case Reports: We report on 4 patients who were referred to the clinic withsuspected acute hepatitis and to investigate high transaminase values. After exclusion of specific hepatitis, unspecific virus hepatitis, autoimmune hepatitis, a metabolic disorder damaging the liver and extrahepatic cholestasis, a toxic liver damage remained as the probable cause and was histologically verified. Since other drugs and alcoholics could be eliminated as possible causes of the damage, the toxicity had to be attributed to statin ingestion. Clinical Course: After discontinuation of the the medication with continuation of all other therapeutic agents of the general practitioners, the transaminase values normalized within a few weeks. Renewed administration of statin was not prescribed for ethical reasons. Conclusion: Therefore, when prescribing a HMG-CoA-reductase inhibitor, thepossibility of liver damage should be mentioned and regular checks of the transaminase values should be performed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 20:42:51